This article describes the hospice nursing experience of a young adult with giant cell tumor of bone with lungs, intra-abdominal muscle, and bone metastases. The nursing period lasted from October 10th to October 26th, 2015. The physical, psychological, social, and spiritual aspects of the patient were integrated into a holistic nursing assessment. The following major health issues were identified: chronic pain, death anxiety, and grief of family members. During the nursing process, apart from medication for pain control, the nursing intervention of applying pillow, music therapy, massage, and adjusting a comfortable position to alleviate cancer-related discomfort were provided. When facing patient’s apathy, anxiety, and unwilling emotions,