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Acetaminophen Synthesis Lab Report

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Purpose The aim of this experiment is to an amide is created by treating an amine with acid anhydride during acetaminophen preparation. Acetaminophen (p-acetamidophenol), the amide, is produced when the amine p-aminophenol is subjected to treatment by acetic anhydride. Experiment Data/Results We started this experiment by obtaining a 50 mL Erlenmeyer flask so we are able to transfer the compounds needed for this reaction mixture. We weighed about 1.5008 grams of p-aminophenol and placed this directly into the Erlenmeyer flask. By using a graduated cylinder, we obtained 4.5 mL of water and 1.7 mL of acetic anhydride, followed by the addition of a magnetic stir bar into our Erlenmeyer flask. Once we have all the components we need in the …show more content…

It can be administered to patients with mild to moderate pain by itself or in conjunction with an opioid analgesic for severe pain. The mechanism of …show more content…

We added a magnetic stir bar to mix the components thoroughly for the next step of heating them. Since this mixture is a reaction mixture we are going to use a hot plate to heat up the reaction mixture at about 90 ℃. The reason why we are using this temperature range is due to the fact of p-aminophenol has a boiling point of 284 ℃. We only need a certain amount of heat to keep the p-aminophenol and force the mixture to react with the heat, the best temperature range is 90-100 ℃ for this reaction mixture. We observed the reaction mixture temperature carefully by using a thermometer so the temperature does not go lower or higher than the desired temperature range. If this were to happen, the reaction mixture would produce a completely different reaction or a certain component would have been missing (dissolved) within the reaction mixture. Throughout the heating process, we observed the solid being dissolved, precipitated, and, redissolved. This was able to happen because paracetamol and acetic acid are the byproducts of the primary reaction that occurs when p-aminophenol and acetic anhydride react. This response is completed in three unique solvents; iso-amyl alcohol, water, and 2-propanol. In addition, the reaction can be carried out with or without impurities. The hydrolysis reaction between acetic anhydride and water produces H+ when water is

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Observations The purpose of this experiment was to be able to synthesize triphenylmethyl bromide from triphenylmethanol by a trityl carbocation intermediate. During the experiment, 0.100 g of triphenylmethanol was placed into a small test tube. The triphenylmethanol looked like a white powder. Next 2 mL of acetic acid was added to the test tube and the solution turned a cloudy white color.

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The Hydrolysis reaction included an acidic environment and an acidic catalyst to make the reaction occur faster and initiate the reaction as well. The acidic environment is required in order to add the hydrogen and oxygen onto the carbonyl groups in the final product. Dicarboxylic acid is not very soluble in water/acetone which ultimately resulted in larger yield of product. 2.

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Lab Report 5: Acetylsalicylic Acid (Aspirin) Synthesis Name: Divya Mehta Student #: 139006548 Date Conducted: November 19th 2014 Date Submitted: November 26th 2014 Partner’s Name: Kirsten Matthews Lab Section: Wednesday 2:30 L9 IAs Name: Brittany Doerr Procedure: For the procedure, see lab manual (CH110 Lab Manual, Fall 2014) pages 96-98. Wilfrid Laurier University Chemistry Department. Fall 2014. Acetylsalicylic Acid (Aspirin) Synthesis.

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However, in this particular experiment, despite this deviation, aspirin, caffeine and acetaminophen compounds were successfully isolated from the analgesic

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Structural Features Acetaminophen is a molecule that is made of twenty atoms; its bonds consist of fourteen single bonds and four double bonds. Acetaminophen is also composed of clusters atoms with groups with names. First of all, part of an acetaminophen atom is a benzene ring. A benzene ring is a ring of six carbon atoms that are connected to each other by three double bonds and three single bonds and unusually all the bond are the same size. In addition, to make sure all the electrons in the outer valence are used the there are hydrogen atoms bonded to stabilize the carbon atoms.

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The main objective of this experiment was the formation of phenacetin from the synthesis of acetaminophen. This was done through a chemical reaction known as the Williamson ether synthesis using techniques of refluxing, vacuum filtration and recrystallization incorporating a mixed solvent system. A further objective of this experiment was to study the formation of the product (phenacetin). Such validation was completed by using techniques for determining the melting point, calculating percent yield, and IR (infrared spectroscopy) of the resultant product.

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In addition, phenolphthalein was added as an indicator. The aliquots were titrated against sodium hydroxide (NaOH) solution until end point was reached, after which volume of NaOH consumed was recorded. The value of the rate constant, k, obtained was 0.0002 s-1. The experiment was then repeated with 40/60 V/V isopropanol/water mixture and a larger value of k = 0.0007 s-1 was obtained. We concluded that the rate of hydrolysis of (CH3)3CCl is directly proportional to water content in the solvent mixture.

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Filtered the solution through 0.45 µm nylon filter Buffer having pH 3.70 used as Mobile phase A and mixture of methanol, acetonitrile and tetrahydrofuran (50: 50: 2 v/v/v) were used as Mobile phase B. Diluent: Prepared a mixture of buffer and methanol (80: 20 v/v). Placebo preparation (Placebo I): Weighed accurately and transferred 255 mg of placebo to a 100 mL volumetric flask. Add 40 mL of methanol and sonicated for 10 mins and add about 30 mL of diluent and again sonicate for 15 mins. Allow to equilibrate at room temperature (RT) and dilute to volume with diluent.

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Lecturer Date Introduction Theoretical Background Procedure The procedure was segmented into two categories, the reaction set up and the crude product isolation. Reaction set up The magnetic stirrer was prepared through placing it in the fume cupboard. 1 mmol of L-Phenylalanine was placed and weighed in a 5 mL conical vial.

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3mL of strong smelling, clear colorless acetic anhydride liquid was then measured in a 10mL graduated cylinder in the fume hood, and poured into the Erlenmeyer flask. The flask was then gently swirled while 5 drops of 85% phosphoric acid was added to the flask. During this time, the solution in the flask was whitish and cloudy. Phosphoric acid was used in the synthesis to become a source of H+ ions that would catalyze the reaction. Phosphoric acid is a liquid that doesn 't contain much water, since water will cause side reactions and reduce the yield of acetylsalicylic acid.

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The hydrolysis formed salicylic concentration which was mixed with iron(III) solution to form a purple complex. This was then use to study under the UV/Visible absorption spectroscopy which gave absorbance values recorded at 525nm to determine the concentration of salicylic acid using the Beer Lambert’s Law and later corrected to find the actual concentrations. The concentrations of aspirin at various intervals was found from salicylic concentrations. Upon plotting a graph of ln(aspirin) vs time, it produced a linear equation from which the gradient gave the rate constant of 0.0083min-1 and the overall shape of the graph concluding this reaction to be pseudo first order with respect to the concentration of aspirin with the deviations and improvements as

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To analyze the acetanilide product of the reaction, 1H NMR and IR were used. Results, Discussions, and Conclusions In this experiment, acetanilide was synthesized via nucleophilic acyl substitution from both acetic anhydride and aniline. During this reaction, aniline acts as the nucleophile and acyl (CH3CO-) group from acetic anhydride acts as the electrophile.

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Aspirin is synthesized through three different steps, the synthesis of the aspirin, the isolation and the purification and finally the purity estimation of the final product. It involves the reaction of acetic anhydride and salicylic acid in the presence of phosphoric acid = H3PO4. After the aspirin is synthesised it then mist be isolated form the reaction solution and purified. This procedure is a possible experiment to execute at a

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