ipl-logo

Acetylsalicylic Acid Synthesis Lab Report

704 Words3 Pages

Lab Report 5: Acetylsalicylic Acid (Aspirin) Synthesis Name: Divya Mehta Student #: 139006548 Date Conducted: November 19th 2014 Date Submitted: November 26th 2014 Partner’s Name: Kirsten Matthews Lab Section: Wednesday 2:30 L9 IAs Name: Brittany Doerr Procedure: For the procedure, see lab manual (CH110 Lab Manual, Fall 2014) pages 96-98. Wilfrid Laurier University Chemistry Department. Fall 2014. Acetylsalicylic Acid (Aspirin) Synthesis. Pages 96-98 in Chemistry 110 Lab Manual. Wilfrid Laurier University, ON, Canada. Abstract: The purpose of this experiment was to determine the level of purity by using the values for melting point and absorbance and chemically synthesizing aspirin by using phosphoric acid as a catalyst. Pure ASA crystals are isolated from the solution with a Hirsch Funnel that was used with a filter. The melting point of the pure ASA crystals were calculated in order to calculate of absorbance. Iron (III) salicylate dianion must contain the acidified solution Fe3+ in order to measure the absorbance values. The level of the impurity can …show more content…

Results: Table 1: Results from the Salicylic acid (g) and the Purity of ASA (g) Experiment Mass of salicylic acid (g) 0.14 g Mass of filter paper (g) 0.47 g Mass of “impure” ASA + filter paper (g) 0.56 g Mass of prepared “impure” ASA (g) …show more content…

The powder on the filter paper could've fell and this caused it to have a smaller percent purity, percent yield and also cause a lower absorbance and concentration of pure ASA. Another error would be not using a properly dried sample for the pure ASA in part C when making the crystals, this could have cause tye percent yield error. This would make a lower melting point. To prevent this from occurring next time there could be a dry sample that is completely dry and this would not alter the mass of the sample and this would make the solution have a more

Show More
Related
358 Words | 2 Pages

As previously stated, the following are the calculated RF values for each plate, Plate 1: Acetaminophen; Acetaminophen (Isolated)- 4.0/6.9= 0.57, Acetaminophen (Pure)- 3.8/6.9=0.55, Excedrin- 4.2/6.9=0.61 Plate 2: Caffeine; Caffeine (Isolated)- 1.9/6.8=0.28, Caffeine (Pure)- 0.8/6.8=0.12, Excedrin-4.0/6.8=0.59 and Plate 3: Aspirin; Aspirin (Isolated)-6.2/7.5=0.83, Aspirin (Pure)-6.2/7.5=0.83, Excedrin-6.8/7.5=0.9. The yield of each isolated analgesic was not calculated. The Rf values of the isolated acetaminophen, pure acetaminophen and Excedrin were all within 0.06. This is most likely due to the contamination of the TLC plate with Excedrin. During plating, drops of the Excedrin solution may have been introduced to the plate.

Read More
363 Words | 2 Pages

Therefore, liquid-liquid and acid-base extraction techniques were successfully performed to separate the components of the Excedrin tablet. According to the TLC analysis results, the compounds (aspirin, acetaminophen, and caffeine) were successfully isolated from the analgesic (Excedrin tablet). In figure 1, the separation of the compound in the TLC analysis correlates with the TLC analysis in figure 2. Furthermore, Rf index calculations of the TLC analysis demonstrated that the compounds (aspirin, acetaminophen, and caffeine) were separated. The Rf calculations of aspirin in table 1 shows an Rf value of .491; however, in table 2 the Rf value of aspirin was calculated to be .784.

Read More
300 Words | 2 Pages

The difference in this chemical and physical properties will aid in their separation. Processes like solubility, gravitational filtration and recrystallization will be used to separate the substances present in Panacetin. The melting and boiling point of the substances will help in concluding on which of these compounds will be presented at the end of experiment. Procedure and observation The Panacetin content was weighed approximately 3.0493g and transferred to the Erlenmeyer flask; 75ml of dichloromethane (CH¬2CL2) was added to the content. The dichloromethane (CH2Cl2) dissolved the sucrose, leaving the active unknown agent and aspirin behind.

Read More
500 Words | 2 Pages

The unknowns were all basic except for the acetylsalicylic acid which was an acid and pseudoephedrine hydrochloride which was a neutral pH when tested. We tested our unknowns and found that both had a basic pH when tested. When we tested the ingredients for acetone solubility we found that most of the ingredients were acetone soluble except for acetaminophen, cornstarch, and sugar. For unknown A we

Read More
659 Words | 3 Pages

In the end, it was concluded that Unknown 30A may have a low molecular weight and was an amine because it turned the red litmus paper blue, after being soluble in water. Therefore, the solubility of the unknown occurred due to weak intermolecular attractive forces of hydrogen bonds. Small amines form hydrogen bonds in water. As a result, the litmus paper turned red to blue because the amine accepted protons from their bond with water molecules, and was basic.

Read More
1525 Words | 7 Pages

In all trials, some of the precipitate was lost through the filter. Therefor all values are most likely less than the actual values due to

Read More
563 Words | 3 Pages

Firstly, because the NaHCO3 compound was not stored in a sealed container, therefore dust particles could have changed the results, and making the product impure. Also, there are uncertainties associated with the instruments used in this experiment. This, if the products were measured slightly more than should be, this could have affected the concentrations of the solutions, and therefore causing a larger

Read More
335 Words | 2 Pages

Experiment # 3 – Resolution Of ( )- -Phenylethylamine Name: Krishna Binu Class: Chem 2020 Due Date: October 23, 2015 Table 1 Shows the experimental results. Name Result Mass of Amine (g) 3.32 Mass of Salt (g) 1.26 Observed Rotation of Isolated Amine (Degrees) -36.33 1) Draw the chemical structures of the two diastereomeric salts produced in Part A using a proper perspective (line-angle) representation.

Read More
424 Words | 2 Pages

The main objective of this experiment was the formation of phenacetin from the synthesis of acetaminophen. This was done through a chemical reaction known as the Williamson ether synthesis using techniques of refluxing, vacuum filtration and recrystallization incorporating a mixed solvent system. A further objective of this experiment was to study the formation of the product (phenacetin). Such validation was completed by using techniques for determining the melting point, calculating percent yield, and IR (infrared spectroscopy) of the resultant product.

Read More
1065 Words | 5 Pages

Aspirin is considered a “polydrug” due to its variety of uses stretching from pain-relief to disease prevention. Salicylic acid is derived from the bark and leaves of the willow tree. Salicylic acid belongs to a group of phytochemicals which have been shown to have positive effects on human health. Salicylic acid is a phenolic compound that can be found in a variety of plants and is a crystal organic carboxylic acid. However, it is more commonly viewed as the primary metabolite and active compound of acetyl salicylic acid, which has been used as an anti-inflammatory drug by physicians for over 100 years.

Read More
1539 Words | 7 Pages

Introduction The goal of the experiment is to examine how the rate of reaction between Hydrochloric acid and Sodium thiosulphate is affected by altering the concentrations. The concentration of Sodium thiosulfate will be altered by adding deionised water and decreasing the amount of Sodium thiosulphate. Once the Sodium thiosulphate has been tested several times. The effect of concentration on the rate of reaction can be examined in this experiment.

Read More
712 Words | 3 Pages

Metabolic engineered of biocatalyst: A solution for PLA based problems ABSTRACT Poly lactic acid(PLA) is a biodegradable polymer used in many biomedical as well as in packaging Applications. Conventionally, PLA is produced by two method which is direct condensation of lactic acid and ring opening polymerization. The polymer produced from these conventional methods produced polymer which have low molecular weight.

Read More
895 Words | 4 Pages

4.2 PREFORMULATION STUDIES PREFORMULATION STUDIES Preformulation testing is an investigation of physical and chemical properties of a drug substance alone and when combined with excipients. It is the first step in the rational development of dosage forms. Preformulation commences when a newly synthesized drug shows sufficient pharmacologic promise in animal models to warrant evaluation in man.

Read More
4301 Words | 18 Pages

This lab also tested basic chemistry techniques and calculations. The experiment consisted of making standard solutions that contained manganese (Mn) and 5% concentrated nitric acid (HNO3) that were measured for absorption to find their concentrations. Two unknowns were also measured and later their concentrations were calculated as well. The metal element of interest, in this case Mn, is measured in atomic absorption as how much light at a specific wavelength is absorbed when it goes through the atoms in the sample.

Read More
2057 Words | 9 Pages

The reagents used were Diphenylamine reagent which contains concentrated H2SO4. The standard solution used for this test is the deoxyribose standard solution. In the sample, only a faint blue solution appeared, which indicates a small presence of deoxyribose. In test for Phosphate, the standard solution was the Phosphate solution and the reagents used were concentrated H2SO4, concentrated HNO3, 2.5% ammonium molybdate solution.

Read More

More about Acetylsalicylic Acid Synthesis Lab Report

Open Document