Burn Wound Case Study

Burn wound size reduction
By measuring the burn wound area before and after definite intervals of time, reduction in burn wound defect area was calculated using equation. At 3rd day there was no reduction in burn wound injury in all the groups. At 7th day there was not much reduction in burn wound for group A (control) and B (conventional marketed cream). There was 77% reduction in burn wound of group D at 7th day post-wounding. At 10th day post-wounding, burn wound healing started leading to about 54%, 66%, 71% and 88% fill in burn wound defect for group A, B, C and D respectively (Table VI). However, at 14th day post-wounding, burn wound defect filled upto 99% in case of test wounds (Group D) and about 94% in burn wounds treated with hydrogel alone (Group C) whereas for control wounds (Group A) and wounds treated with conventional marketed cream (Group B) this was about 71% and 84% respectively. Statistical analysis showed that there was significant (p<0.05) difference in burn wound size reduction between test wound treated with SSD incorporated hydrogel (Group D) and burn wounds treated with conventional marketed cream (Group B). Histological analysis

This is associated with mild contracture of burn wounds. Burn wound contraction is mediated by specialized phenotypically altered fibroblasts found within the granulation tissue. Burn wound contraction seen in burn wounds treated with SSD loaded hydrogel can be due to the enhanced activity of these fibroblasts. Formation of keratinocytes with melanin pigment was observed on 7th day post treatment. Granulation tissue was formed in dermis on 7th day post-treatment. Bacterial colonies and inflammatory cells were absent. Even though the test burn wounds were almost completely healed, foreign body reactions were still found in the dermis, which can be attributed to the degradation of the hydrogel