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Solubility Lab Report

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Solubility Enhancement by Chemical Modification Method Abstract Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system. It is an important parameters to achieve optimum concentration of drug in systemic circulation for desired pharmacological response. Oral route is the most desirable and preferred method of administering therapeutic agents for their systemic effects, but poor solubility of drug major problem encountered with formulation development of new chemical entities. About 40% NCEs (new chemical entities) developed in pharmaceutical industry suffer from formulation difficulties related to their water insolubility. For the absorption of any drug, the drug must be present in its chemical …show more content…

The solubility of a substance fundamentally depends on the solvent used as well as on temperature and pressure. The extent of solubility of a substance in a specific solvent is measured as the saturation concentration where adding more solute does not increase its concentration in the solution [1]. IUPAC defines solubility as the analytical composition of a saturated solution expressed as a proportion of a designated solute in a designated solvent. Solubility may be stated in units of concentration, molality, mole fraction, mole ratio, and other units …show more content…

Lachman, H. Lieberman, and J. L. Kanig, The Theory And Practise of Industrial Pharmacy, Lea & Febiger, 3rd edition,1986. [2] “IUPAC gold book,” http://goldbook.iupac.org/S05740.html. [3] Loyd V.Allen, Jr., Nicholas G. Popovich, Howard C. Ansel , Ansel’s Pharmaceutical Dosage Forms and Drug delivery System, p 100, 8th edition,2005. [4] The United States Pharmacopeia, USP 30-NF 25, 2007. [5] British Pharmacopoeia, 2009. [6] The Biopharmaceutics Classification System (BCS) Guidance. Available from: http://www.fda.gov/AboutFDA/CentersOffices/OfficeofMedicalProductsandTobacco/CDER/ucm128219.htm [Last accessed on 2016 Aug 3]. [7] Gennaro A.R. editors. Remington, the science and practice of pharmacy, 21st ed. Lippincott, Williams & Wilkins, 2005; 867-868. [8] Fiese E.F, Hagen T.A. Preformulation. In: Lachman L, Liberman H.A, Kanig J.L, editors. The theory and practice of industrial pharmacy. 3rd ed. Bombay: Varghees Publication House, 1990; 171-196. [9]Venkatesh S, Y, Rao V, Anderson B. D, Intrinsic solubility estimation and pH-solubility behavior of cosalane (NSC 658586), an extremely hydrophobic diproticacid, Pharmaceutical Research, 1996; 13(10),

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