Solubility Enhancement by Chemical Modification Method Abstract Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system. It is an important parameters to achieve optimum concentration of drug in systemic circulation for desired pharmacological response. Oral route is the most desirable and preferred method of administering therapeutic agents for their systemic effects, but poor solubility of drug major problem encountered with formulation development of new chemical entities. About 40% NCEs (new chemical entities) developed in pharmaceutical industry suffer from formulation difficulties related to their water insolubility. For the absorption of any drug, the drug must be present in its chemical …show more content…
The solubility of a substance fundamentally depends on the solvent used as well as on temperature and pressure. The extent of solubility of a substance in a specific solvent is measured as the saturation concentration where adding more solute does not increase its concentration in the solution [1]. IUPAC defines solubility as the analytical composition of a saturated solution expressed as a proportion of a designated solute in a designated solvent. Solubility may be stated in units of concentration, molality, mole fraction, mole ratio, and other units …show more content…
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