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Doege-Potter Syndrome Case Study

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Recommended: Diagnostic challenges in Doege--Potter Syndrome

Doege-Potter Syndrome, cause of non-islet cell tumor hypoglycemia, the first case report from Nepal. Abstract Doege–Potter syndrome (DPS), a paraneoplastic syndrome, presents as a hypoinsulinaemic hypoglycemia from the ectopic secretion of insulin-like growth factor II (IGF-II) from a solitary fibrous tumor which may be intrapleural or extrapleural in origin. We report a case of severe hypoglycemia in a 68-year old lady initially admitted for resection of left sided solitary fibrous tumor of pleura (SFTP). Investigation revealed true hypoglycemia and DPS was diagnosed. The tumor was completely resected and the patient made a full recovery with no further hypoglycemic episodes. This is probably the first case of SFTP with DPS reported from …show more content…

The admission prior to surgery was complicated by hypoglycemia, leading to cancellation of the surgery. Surgery was postponed until an endocrinology evaluation was completed. There was absence of any underlying endocrine pathology. The administration of hypoglycemic agent was ruled out. The patient was clinically Whipple’s triad positive suggesting true hypoglycemia. He was also found to have normal thyroid and adrenal function insulin level of <3 mU/L [3.0-25.0 mU/L]Serum C-peptide level was below 0.05ng/ml which was very less (Ref: 0.81-3.85 ng/ml). Anti-insulin antibody was …show more content…

Kalebi AY, Hale MJ, Wong ML, Hoffman T, Murray J. Surgically cured hypoglycemia secondary to pleural solitary fibrous tumour: case report and update review on the Doege-Potter syndrome. Journal of cardiothoracic surgery. 2009 Aug 18;4(1):45. 2. Daughaday WH, Kapadia M. Significance of abnormal serum binding of insulin-like growth factor II in the development of hypoglycemia in patients with non-islet-cell tumors. Proceedings of the National Academy of Sciences. 1989 Sep 1;86(17):6778-82. 3. England DM, Hochholzer L, McCarthy MJ. Localized benign and malignant fibrous tumors of the pleura: a clinicopathologic review of 223 cases. The American journal of surgical pathology. 1989 Aug 1;13(8):640-58. 4. Gold JS, Antonescu CR, Hajdu C, Ferrone CR, Hussain M, Lewis JJ, Brennan MF, Coit DG. Clinicopathologic correlates of solitary fibrous tumors. Cancer. 2002 Feb 15;94(4):1057-68. 5. Santos RS, Haddad R, Lima CE, Liu YL, Misztal M, Ferreira TD, Boasquevisque CH, Luketich JD, Landreneau RJ. Patterns of recurrence and long-term survival after curative resection of localized fibrous tumors of the pleura. Clinical lung cancer. 2005 Nov

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