Introduction: In the field of Endocrinology, it is known type 1 diabetes is a result of beta cells in the pancreas, that produce the insulin, are attacked by the immune system. This is the reason that Type 1 diabetes is known as an autoimmune disease. The insulin produced by the beta cells help to lower glucose levels in the blood. In this research that we will be doing in the lab, we will be studying the Estrogen receptor alpha and how that affects beta cells when apoptosis occurs, which causes beta cell numbers to drop. Also especially we will be looking into the effect of the Estrogen receptor alpha on endoplasmic reticulum stress that cause higher levels of apoptosis leading to a lower count of beta cells in the pancreas. The overall goal …show more content…
By analyzing the effects of the Estrogen receptor alpha on beta cells, our lab will be achieving the goal of my lab. We are doing this by observing if Estrogen receptor alpha causes insulin resistance or if it guards beta cells to keep there functionality when apoptosis occurs when there is Endoplasmic reticulum stress. While this project fits directly in line with our objectives at my lab, it also fits into the bigger picture in the endocrinology field. While endocrinology is the study of the hormones and endocrine gland, the main disease that is associated with endocrinologists is diabetes. Diabetes is connected with insulin resistance or beta cell deficiency. By do this research project that deals with the endurance of beta cells in the pancreas, then we will have a better understanding of Diabetes and when the paper s published it could very well lead another research or guide further research into a cure for diabetes. Diabetes means a lot to me, which is the reason why I chose this particular research project and it is also one of the reasons why I chose to join a lab that does research that is related to