Toad belonging to the family bufonidae is different from frog like Rana vittegera even if it was an amphibian. As Kennedy (1982), explained that the large parotid glands on the back of the toad have been described as “veritable chemical factories” and this is the differences between frog from toad; they produce and secrete at least twenty-six compounds, all of which are biologically active that exhibits medicinal property, some of these are the plenylethylamine bases and derivatives such as the catecholamines, dopamine, epinephrine, and norepinephrine as well as a number of indole derivatives such as serotonin that are benign and occur naturally in human tissues, they act as neurotransmitters which connect individual neurons through chemical