Gilbert Syndrome
Gilbert syndrome (also called Gilbert's syndrome) is a common condition where the liver does not process bilirubin, a substance that is produced from the breakdown of your red blood cells. Gilbert syndrome is typically harmless and requires no treatment.
Part 1: What Is Gilbert Syndrome?
Gilbert syndrome is characterized by elevations of unconjugated bilirubin in the blood, which is usually unrecognized until it is seen in a blood test that may be done for other reasons. Fluctuations in bilirubin levels in the blood (or hyperbilirubinemia) that are sometimes associated with yellowing of the skin and eyes occur in people who are diagnosed with Gilbert syndrome. This mild condition, which is otherwise harmless, is often recognized
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These include:
• dehydration
• fasting state
• an infection
• stress
• physical exertion
• lack of sleep
• after surgery
• menstrual periods
Avoiding some known triggers can help reduce having episodes of jaundice.
Part 4: How to Live with Gilbert Syndrome
Gilbert syndrome does not require treatment. Although your bilirubin levels may fluctuate and you may experience jaundice occasionally, this usually disappears on its own, and does not cause any problems.
Gilbert syndrome is a long-term condition that is not a threat to your health. It is not associated with any complications and it does not increase your risk of liver disease. Symptoms are usually short-lived and self-limiting.
There is no need to modify your diet or your daily activities, except to avoid those that trigger your symptoms.
People with Gilbert's syndrome, however, may be at risk of getting jaundice and other side effects when taking certain medications such as:
• Indinavir and Atazanavir (used for treating HIV infection)
• Statins (cholesterol-lowering drugs) plus gemfibrozil
• Gemfibrozil (another cholesterol-reducing drug)
• Irinotecan (used for treating bowel