. DRUG PROFILE 2.1 IBUPROFEN Ibuprofen chemically known as 2-[4-(2-methyl propyl) propanoic acid. It is a propanoic acid derivative classified under non steroidal anti inflammatory agent (NSAID) with analagesic and antipyretic properties.The empirical formula of ibuprofen is C13H18O2 its molecular weight is 206.29. It is indicated for relief of the signs and symptoms of rheumatoid arthritis and osteo arthritis for relief of mild to moderate pain and also indicated for the treatment of dysmenorrheal. MECHANISM OF ACTION The exact mechanism of action of ibuprofen is unknown. Ibuprofen is a non selective inhibitor of cyclooxygenase, an enzyme involved in prostaglandins synthesis via the arachidonic acid pathway.Its pharmacological effects are believed to be due to inhibition of cyclo oxygenase -2(cox2) which decrease the …show more content…
H et. al., developed two new UV spectrophotometric methods and validated for simultaneous estimation of Ibuprofen and Famotidine in a tablet dosage form (DUEXIS). The first method, the absorbance correction method was based on the measurement of the absorbance at two wavelengths namely 287 nm at which IBU has no absorbance while at wavelength 264 nm both drugs have considerable absorbance. The second method was the absorbance ratio method involves formation of Q-absorbance equation at 274.5 nm (isoabsorptive point) and also at 264 nm (λmax of IBU). The methods were found to be linear between the range of 50-800 g/mL for IBU and 3-27 g/ mL for FAMO for both methods. The mean percentage recovery was found in the range of 101.1%-101.84% and 101.84-102.84% for the Absorbance correction method and 99.93-101.14 and 101.62-102.57 for the absorbance ratio method, for ibuprofen and Famotidine respectively at three different levels of standard additions. The precision (intra-day, inter-day) of methods were found within limits (RSD s law in the concentration range of 20-140μg/mL and 2-10μg/mL for ibuprofen and famotidine