Guar Gum Essay

Literature Review Guar gum is the powder of the endosperm of the seeds of Cyamopsis tetragonolobus. It is white to pale yellowish powder with characteristic odour. It is partially insoluble in organic solvents. It is hydrophilic polymer and in cold water it swells up forming viscous colloidal dispersions or sols. Hydration of the gum occurs in cold water, which give gelling property to guar gum. (Krishnaiah et al ., 1988, Krishnaiah et al ., 2002) confirmed its role as a carrier by both in- vivo and in – vitro. Due to its release retarding property and susceptibility to microbial degradation in the large intestine, Guar gum was found to be a colon-specific drug carrier in the form of matrix and compression-coated tablets as well

it is an anti-protozoal drug. It is a congener of metronidazole similar to it in every respect, except Less side effects, better tolerability . It is a BCS class 2 drug having low solubility. It is slightly soluble in water ,soluble in acetone,sparingly soluble in methanol and ethanol. Tinidazole , chosen in the current studies, is a poorly water-soluble drug known to demonstrate dissolution or solubility limited absorption . Although the mean bioavailability of the drug is low, yet its rate of absorption is quite inconsistent and delayed with time. Based upon its aqueous solubility and various dissolution parameters, the drug bioavailability can unambiguously be regarded as limited solely to dissolution ( Chhaprel et al., 2012). Solubility of Tinidazole has been enhanced in the literature by preparing solid dispersion using hydrophilic polymers like guar gum, xanthan gum, Polyethylene glycols (PEG 4000), Hydroxypropyl Methyl cellulose (HPMC 5cps) and chitosan in tablet manufacturing of Tinidazole tablets. (Iyer et al ., 2013) prepared colon specific fast disintegrating tablets of solid dispersion of Tinidazole with various hydrophilic carriers such as PEG 6000, poloxamer 188, PVP, HPMC100LV for solubility enhancement of Tinidazole and concluded that solubility and dissolution rate of the tablets was enhanced (Singh et al ., 2011). (Katare et al., 2012) prepared solid dispersion of curcuminoids using guar gum as carrier and concluded that solubility of solid dispersion of curcuminoids was enhanced using hydrophilic carrier guar gum than pure curcuminoids. (Bolla et al .,2013) prepared solid dispersion of simvastatin using karaya gum, oat powder, chitosan and concluded that solubility of the drug was enhanced with solid dispersion