Signs of ossification start to appear in childhood. Abnormality of the great toe is the most common finding and often noticeable at birth (8). Except for this abnormality, children with FOP are normal at birth. Other signs of fibrodysplasia ossificans progressiva will start when large lumps form on the back and neck in the first two decades of a child’s life. This will then turn into bone. Forming of bones normally occur during early childhood, but also during early adulthood or throughout life. Most people will know they have the disease before they are ten years old. Live expectancy of FOP patients is 28.7 years.