Tetracycline Case Study

DISCUSSION – This study was conducted to evaluate the efficacy of 1% Alendronate gel and tetracycline fibers as an adjunct to scaling and root planing. The study was conducted on 30 subjects with a split mouth randomized controlled clinical design . The efficacy was determined based on the clinical parameters of the two groups that is Group I (treated by 1% Alendronate gel) and Group II (treated by tetracycline fibers).In order to overcome the drawbacks associated with systemic and conventional mode of therapy ,local drug delivery system were administered ,which were used in this study. Most widely used local drug delivery system in periodontal literature is Tetracycline as reported by Goodson. [13] Tetracycline inhibits collagenase activity, collagen degradation and bone resorption as reported by Golub et al. [14] They exert their antimicrobial effect by inhibiting microbial protein synthesis. In the present study the results showed statistically significant reduction in pocket probing depth (PPD) from baseline to 6 months in both the Test and the Control groups. (p=0.002).
Similarly , in both the Test and the Control groups there was a statistical

[19] in a monkey model of periodontitis treated with Alendronate did not observe an effect on probing depth measurement.As per the results of present study , there was significant improvement in all clinical parameters with the Alendronate group having comparatively better result than Tetracycline group. The Alendronate group has an upper hand in terms of periodontal therapy since it gives us a maximum reduction in all clinical parameters. Alendronate is known to act on the bone surface for inhibition of the osteoclastic activity. Within limits superimposed by a relatively smaller sample size ,the present study shows improvements in clinical parameters both in Group I and II .However ,the Group I showed better result in terms of Clinical Attachment Level gain, Clinical probing depth and