1. Introduction
Due to the extensive use of pharmaceutical active compounds (PhACs), a wide range and different of PhAC residues occurs in the aquatic environment. Their fate is potentially a major issue that is yet to be understood [1].Extensive use of antibiotics for disease prevention, treatment of microbial infections and promotion of animal and plant growth have led to the frequent detection of different antibiotics and their by products in the environment [2,3]. The antibiotics distribution in the environment can increase the resistance of bacteria and subsequently compromise public health by preventing treatment of infections caused with these bacteria [4]; and this is one of the major challenges for human and veterinary medicine. one of the most widely used antibiotics in human and veterinary medicine is Ciprofloxacin (CIP), that is a third-generation of Fluor quinlones. It is used in various infections such as of the urinary, respiratory and gastrointestinal tract, as well as in skin structure and optical infections. Ineffective removal
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The studies using the experimental designs showed the relevance of this methodology [22]. Several studies have used AOPs for the degradation of antibiotics, but the application of Full factorial method for designing the experiment by Fenton process has not yet been reported. In In this work, we was performed the optimization of the degradation of CIP in aqueous solution by Fenton process, by using a 24 factorial experimental design. Four factors were chosen to build the full factorial design with two levels. The effects of factors and their interaction and suitability of the chosen model with the response have been studied. Pharmaceutical wastewater from a large number of manufacturing units is extremely contaminated by ciprofloxacin (CIP), an antibiotic