Dental caries is one of the most common and2 multifactorial human diseases that has widely affected vast majority of individuals all over the world3.It is induced by acids developed by the dental plaque adhering to the tooth surface.4 Different circumstance effect dental aspect.Interaction between detrimental and defensive factors are crucial.Microorganisms, sugar, and unhealthy eating habits are disastrous to dental aspect, while saliva, oral hygiene, and the natural resistance of the teeth serve as the defensive equilibrium.1
Bacterial plaque plays the initial role in the pathogenesis of the disease. Dental plaque is a ordinary term for the diverse microbial community (predominantly bacteria) found on the tooth surface, fixed in a matrix of polymers of bacterial and salivary origin. Plaque is an example of a biofilm; current researches are showing that the properties of bacteria associated with a surface in a biofilm.In other words plaque is found at protected and stagnant surfaces, and these are at the greatest threat of disease .3
Diet has a local response on oral health, primarily on the integrity of the teeth,pH, and composition of the saliva and plaque. Nutrition, however, has a systemic response on the integrity of the oral cavity, including teeth, periodontium
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From diverse parts of neem more than 140 compounds have been isolated. All parts of the neem tree- leaves, flowers, seeds, fruits, roots and bark have been used traditionally for the treatment of inflammation, infections, fever, skin diseases and dental disorders. The medicinal utilities have been described especially for neem leaf. Neem leaf and its constituents have been verified to exhibit immunomodulatory, antiinflammatory, antihyperglycaemic, antiulcer, antimalarial, antifungal, antibacterial, antiviral, antioxidant, antimutagenic and anticarcinogenic properties .