Capsule is a solid dosage form which contain active pharmaceutical ingredient encompass with different types of shells and sizes. They are made of different composition but mostly it is made with Gelatin extracted from animal bones and skin (choudhary, 2008-2017). There are two main types of Capsules 1- Hard Gelatin Capsule a. Hard gelatin capsules normally come in two pieces body and cap and normally they are cylindrical shape or bullet shape. b. API 's are powders, granules, tablets and pallets coated drugs which are encapsulated in hard shell. c. Gelatin is hard, but they are water soluble and biodegradable shells. d. Hard capsules are normally sealed after they been filled properly ensuring the API 's does not comes out when handle. e. Hard capsules come in eight different sizes. 2- Soft Gelatin Capsule: a. …show more content…
To achieve good results, we need to introduce high sheer blender typically performed v- blenders with high speed intensifier bar which keep powder dry, maintain their shape, size and reduce lumping together. Particle with isometric shape and they are round are best for hard capsule while anisometric shape is having problem with the flowability and they have higher tendency to adhere with walls and they take more surface area. b- Particle solubility: Solubility depends on lot of factor like shape and size long with their capacity to dissolve and disintegrates in solvents. Fine particle of powders like small size, round shape with anhydrates capability of particle will dissolves and disintegrates quicker than that of crystalline with anisometric shape which have slower dissolving and disintegrating properties. c-