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A Summary Of Febuxostat

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3.Pharmacology 3.1.Mechanism of action Febuxostat is a non purine compound and selective inhibitor of xanthine oxidase that has been developed for the treatment of hyperurecemia and gout. It has been found to have inhibitory activity for xanthine oxidase(XO)/xanthine dehydrogenase(XDH) during evaluation of a range of newly synthesized molecules. In humans, the xanthine oxidoreductase enzyme(XOR) catalyzes the last 2 steps in uric acid synthesis,the oxidation of hypoxanthine to xanthine and xanthine to uric acid. febuxostat was shown to inhibit both oxidized and reduced forms of XO unlike allopurinol or oxypurinol which binds only to one form of enzyme. Figure 3. mechanism of action of febuxostat Febuxostat reduces the production of uric acid by non-competitively blocking the molybdenum-pterin center which is the active site on xanthine oxidase. Febuxostat does not structurally resemble purines and pyrimidines and has no significant effect on the activities of other enzymes which are involved in purine and pyrimidine metabolism. Febuxostat provides protection against hyperurecemia and acute renal failure caused by excessive release of uric acid …show more content…

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