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Giant Cell Tumor Case Study

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Metachronous Multicentric Giant cell tumor: a case report ABSTRACT Multicentric giant cell tumors represent less than 1% of all giant cell tumors of bones. We report a case of young girl with metachronous multicentric giant cell tumors with 5 documented lesions in a monomelic lower limb. The initial lesion started during the first trimester of her pregnancy around her right pelvis and resulted in rapidly progressive painful swelling with restricted mobility of her right hip joint. These tumors had typical radiological appearance and the diagnosis of giant cell tumor was confirmed on histopathology. She was managed by an aggressive surgical approach for knee and talar lesions, whereas repeated embolization was done to treat her pelvic lesion. …show more content…

Rock MG. Curettage of giant cell tumor of bone. Factors influencing local recurrences and metastasis. Chir Organi Mov 1990; 75 Suppl 1: 204-205. 7. Goldenberg RR, Campbell CJ, Bonfiglio M. Giant cell tumor of bone: an analysis of two hundred and eighteen cases. J Bone Joint Surg 1970; 52-A: 619-664. 8. Jaffe HL, Lichtenstein L, Portis RB. Giant cell tumour of bone. Its pathologic appearance, grading, supposed variants and treatment. Arch Pathol 1940; 30: 993-1031. 9. Xu SF, Adams B, Y XC et al. Denosumab and giant cell tumor of bone- a review and future management considerations. Curr Oncol Oct 2013; 20(5):e442-e447. 10. Mavrogenis AF, Rossi G, Rimondi E et al. Embolization of bone tumors. Orthopedics April 2011; 34(4): 303-310. 11. Yanagawa T, Watanabe H, Shinozaki T et al. Usefulness of FDG PET in primary bone tumors. The Open Bone Journal 2010; 2: 19-23. Learning points: • Multicentric giant cell tumors of the bone are rare entity and usually affect younger females • Multiple bone involvement can occur simultaneously (synchronous) or at different times (metachronous) • Denosumab and selective embolization of the tumour is useful palliative treatment for inoperable tumors • PET scan is an effective investigation tool for the diagnosis and evaluating these

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