Growth Hormone Syndrome Analysis

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Growth hormone insensitivity (GHIS) can be defined as the clinical and biochemical features of IGF-I deficiency associated with normal or elevated GH secretion. Laron syndrome is considered the classical form of GHIS [Savage et al., 2001]. First described by Laron et al as a new entity in 1966, Laron syndrome (MIM 262500) is an autosomal recessive disorder caused by mutations of the growth hormone receptor gene (GHR) [Laron and Klinger 1994]. Endocrinologically, Laron syndrome is characterized by severe short stature, normal or high serum GH levels, and very low serum IGF-I and IGFBP-3 levels. Other important clinical features of Laron syndrome include small facies, high-pitched voice, normal body proportions in childhood and childlike body

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