Hyperlipidemia

Effects of High cholesterol diet on cardiac performance

The purpose of this research was to identify how hyperlipidemia affects heart performance. Hyperlipidemia is a condition in which excess cholesterol and triglycerol are present in the blood stream, and this study focused on the impact of high cholesterol. The activation of KATP channels by activators, cromakalim and diazoxide, is a cardioprotective mechanism seen in animals. The study focused on male Wistar rats, where ventricular tissue was extracted and processed for comparison between normal diet and cholesterol fed rats, while many tests included PCR analysis, Western blot analysis, etc. Cholesterol fed rats vs. normal fed rats showed a decrease in cardiac ATP production, an increase

In the study, it emphasizes how high cholesterol impacts the health of rats with a decrease in ATP production, increase of lactate levels, and increase of oxidative stress in myocardium, and this increases the risk of developing cardiovascular disease, known as ischemic heart disease. Avoiding cholesterol completely may harm the body, because cholesterol is needed to produce cell membranes, is the precursor of for the synthesis of hormones and Vitamin D. Part of maintaining these levels is by performing fasting lipoprotein profile test that checks for the LDL (low density lipoprotein) cholesterol, HDL (high density lipoprotein) cholesterol, and the levels of triglycerides in the blood. These levels should remain in the standard ranges based on gender, weight, age, etc. The treatment of this condition will not be discussed in the study, but one may choose to improve their diet or count on drugs specifically HMG CoA reductase inhibitors that reduce the levels of cholesterol and triglycerides in the

Even though there are no symptoms associated with hyperlipidemia, it is important to maintain a balanced level of lipids to prevent health risks such as ischemic heart disease. The study addresses the importance of understanding how hyperlipidemia disturbs the cardioprotection by ATP-sensitive K channels activators, along with an increase in lactate, oxidative stress production, and gene expression. The significance of this study proved for the first time that cholesterol diet prevents cardioprotection from the KATP channels activators cromakalim and diazoxide mentioned. The mechanism of how high cholesterol effects cardioprotection by K channel activators needs to be further investigated to fully understand how hyperlipidemia affects the health of individuals. This will open new directions in finding effective alternate drug targets to protect the cardiac cells in individuals with