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Isoniazid Research Paper

128 Words1 Pages
Hepatic acetylation is the main path of the isoniazid metabolic pathway, with the action of N-acetyl transferase that produces acetylisoniazid. Acetyisoniazid is then hydrolyzed to isonicotinic acid that is conjugated with glycine, and acetylhydrazine, both are excreted in the urine. Acetylhydrazine will be then metabolized to diacetylhydrazine and the hepatic microsomal enzymes may convert it to a hydrazine, which is a reactive metabolite that is responsible for the isoniazid-induced hepatotoxicity. Acid labile hydrazones that are formed with a-ketoglutarate and pyruvate produced in the bladder because they don’t appear in the blood. The rate of this path is genetically determined and is focus to individual variations. It’s constant for

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