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Lesch-Nyhan Syndrome Research Paper

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Lesch-Nyhan Syndrome or LNS exclusively only affects males. The mothers can pass the disease through the X chromosome; therefore, it is denoted as an x-linked recessive disease. This disease can affect approximately 1 in 380,000 births. Lesch-Nyhan Syndrome is an inborn fault of purine metabolism. There are an abundance of symptoms associated with this genetically rare disease. Lesch-Nyhan Syndrome only affects males, because it is only associated on the X chromosome and it is recessive, hence females will not be affected by this disease only males. Mutations on the hypoxanthine phosphoribosyltransferase 1 gene or HPRT1 causes Lesch-Nyhan Syndrome. The cytogenetic position of HPRT1 is Xq26.1. The gene usually encodes the protein called transferase,
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