Case Study 1.1liquisolid Systems Technology

1.1Liquisolid Systems Technology Many recently developed drugs are poorly water soluble compounds, which cause difficulties in the development of solid dosage forms with good bioavailability(1).
The therapeutic effect of the drug is reliant on the bioavailability which in turn relies on the solubility and dissolution rate of the drug, therefore; solubility is the most important factor to get the required concentration of drug in the systemic circulation for therapeutic response to be attained(2). For different poorly soluble medications, bioavailability is limit via the dissolution rate. Furthermore, the majority of the lipophilic drug molecules are sparingly soluble, slightly soluble, very slightly soluble and practical insoluble drugs. For each drug substances mentioned above the dissolution is the rate.limiting step; therefore, enhancing the dissolution rate is the challenge to enhance the absorption of

Liquisolid compacts: Means the formulation of immediate or sustained release dosage forms( tablets or capsules), formulated with addition of suitable excipient required for tabletting; like lubricants, binders or disintegrants..
2. Liquisolid microsystem: Relies on a recent model which utilize same method used for formulation of liquisolid compacts combines with the addition of additives (e.g. poly vinyl pyrrolidone (PVP) in the non volatile liquid which is then incorporated into the carrier and coating materials to make a suitably flowing blend for encapsulation). Liquisolid microsystem offers advantage of that the size of the unit product may be reduced as much as 5 times lower than that of liquisolid systems and conventional products.

Liquisolid systems (LS) may be classified into 3 subgroups, depending on the type of liquid medication that