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Nucleophilic Substitution Reaction Lab Report

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Introduction:- In organic chemistry the substitution reactions is the most important reactions, especially Nucleophilic aromatic substitution reactions where nucleophile attacks positive charge or partially positive charge As it does so, it replaces a weaker nucleophile which then becomes a leaving group. The remaining positive or partially positive atom becomes an electrophile. The general form of the reaction is: Nuc: + R-LG → R-Nuc + LG: The electron pair (:) from the nucleophile (Nuc :) attacks the substrate (R-LG) forming a new covalent bond Nuc-R-LG. The prior state of charge is restored when the leaving group (LG) departs with an electron pair. The principal product in this case is R-Nuc. In such reactions, the nucleophile is usually electrically neutral or negatively charged, whereas the substrate is typically neutral or positively charged. An example of Nucleophilic substitution is the hydrolysis of an alkyl bromide, R-Br, under basic conditions, where the attacking nucleophile is the base OH− and the leaving group is Br−. R-Br + OH− → R-OH + Br− Nucleophilic substitution reactions are commonplace in organic chemistry, and they can be broadly categorized as taking place at a carbon of a saturated aliphatic compound carbon or (less often) at an aromatic or other …show more content…

In the first step, the leaving group departs, forming a carbocation C+. In the second step, the nucleophilic reagent (Nuc :) attaches to the carbocation and forms a covalent sigma bond. If the substrate has a chiral carbon, this mechanism can result in either inversion of the stereochemistry or retention of configuration. Usually both occur without preference. The result is racemization. For an example (the reaction of tert-butyl chloride with water.) The SN2

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