Overactive Bladder Syndrome Case Summary

The following is a case study of female client Patricia Miller had been diagnosed with overactive bladder syndrome. Overactive bladder is a complication with bladder storage function that causes sudden urination urgency. In normal person, nerve send the signal to the brain and trigger the detrusor muscle to contract when bladder is full while in overactive bladder person, brain response causes emptying of bladder by contraction of muscle even though bladder is not full. The urge to urinate will be painful to stop and overactive bladder causes forced loss of urine. When urinate, nerve signals coordinate the relaxation of the trigone muscles and the sphincter muscle. The detrusor muscles of the bladder contract pushing the urine out. Mrs. Miller is 47 years old woman who was been diagnosed with overactive bladder syndrome and on medication of 5 mg Oxybutynin twice daily. Mrs. Miller complained that the side effects of Oxybutynin result her mouth to feel very dry. She also had to get up at night to use the bathroom. During the daytime, she has to urinate about nine times and wears a pad for fear of leaking. Overactive bladder syndrome occurs of uncommon mechanism of M3 muscarinic receptor action. The M3 muscarinic receptor act to be

M3 Cholinergic receptors are the one that responsible for parasympathetic detrusor contraction. Thus oxybutynin compete with acetylcholine (ACh), binding Oxybutynin lead inactivation of Phospholipase C and result in inhibition of Calcium ion releasing and lead to relaxation of detrusor muscle. Oxybutynin studies determine that Oxybutynin can increase maximum urinary bladder holding capacity and increases the volume to detrusor contraction. Oxybutynin is appropriate for the patients that having conditions of involuntary detrusor contractions such as Mrs.