ipl-logo

Praulent Research Paper

824 Words4 Pages

Praulent, a new cholesterol drug, when used with older statin medicines, help lower risk of heart events and deaths. The results of the big study of heart attack survivors were shared on Saturday at an American College of Cardiology conference in Florida. Sanofi and Regeneron Pharmaceuticals, the makers of Praulent which sponsored the study, said they will work with insurers on pricing to get the drug to those who need it the most. While the benefit may appear small, since 167 people have to take the medication for almost three years to prevent a single death, Dr. Philippe Gabriel Steg, from Hospital Bichat in Paris, pointed out that it is the ultimate outcome that matters to patients. High cost However, the high cost of Praulent may deter patients from using the cholesterol-lowering drug. Because the medication costs more than $14,000 a year, insurers have balked at paying for the medication without a proof that it reduces health problems and not just bad cholesterol, CBS reported. …show more content…

The main medicine for reducing bad cholesterol is statins, but some patients cannot tolerate it or do not get enough help from the drug. The study involved both Praulent and a similar medication, Repatha, manufactured by Amgen. But Repatha works in a different way and lowers cholesterol much more. The study on Praulent took a longer time and involved patients at a higher risk of heart events. These were almost 19,000 patients who suffered a heart attack or serious chest pain the previous year that they had to be hospitalized. Even if they had maximum statin use, all of the patients had LDL over 70. Praulent was given to half of the patients and to the other half, placebo. It started at a lower dose and increased if the LDL of the patient did not go down below

Show More
Related
988 Words | 4 Pages

Deep Venous Thrombosis Prophylaxis; Lovenox vs Heparin On June 30, 2011, the Centers for Medicare and Medicaid Services (CMS) presented their final ruling on non-payment policies for provider preventable conditions (PPCs). One of the other provider preventable conditions includes the development of deep vein thrombosis (DVT) prophylaxis in any health care setting (Federal Register, 2011, p. 32817). Due to the significant cost of providing care for preventable conditions that are now not reimbursed through the CMS and many health insurance companies, hospitals around the country have implemented new policies to ensure patients remain free of venous blood clots during their hospital stay. The practice of injecting either Lovenox or heparin

Read More
936 Words | 4 Pages

1. Have began the process of updating the forms for Psychiatric Evaluations as well as the forms to document follow-ups visits (Medication Management). The purpose is to improve the flow of information, simplify its use, assure the appropriate content, and facilitate arriving to the appropriate billing codes. 2. Met with all extended providers, as well as doctors to continue to ensure consistency in the delivery of quality care and the utilization of best practices, Participation in the MACRA/MIPS on a weekly basis 3.

Read More
1446 Words | 6 Pages

However, before combining Cholestoff with statins, it is important to consult a doctor. The pentethine found in Cholestoff Complete has been shown to work effectively in lowering the levels of cholesterol in the body when it blends with stenols and sterols. The amalgamation produces great results because a blend of stanoils, stenols and statins effectively lowers the cholesterol levels. The combinations also greatly reduces the negative effects of statins are greatly reduced, especially when small doses of phytosterols and statins are

Read More
602 Words | 3 Pages

South Asian man are more likely to be blamed for a crime because of their connection to ISIS. Seral is a podcast that is about a Museum boy named Adnan that went against his religion to date a Korean girl named Hae that also went against her religion to date but after a few weeks of breaking up Hae started dating a new guy named Don. Everything was good until a few weeks later Hae went missing and was late found dead in Leakin Park. Adnan friend and drug deal Jay told the police that he was with Adnan at the time that he was buring Hae’s body. The police ended up chagrining Adnan for the murdered.

Read More
866 Words | 4 Pages

West Encyclopedia (2005) studies show that “The FDA annually regulates over $1 trillion worth of products, which accounts for one-fourth of all consumer spending in the United States.” The FDA protect patients’ rights and safety in clinical trials of new medical products, monitor promotional activities and regulate labeling of packaged foods. The FDA is responsible for monitoring the safety of the nation’s blood supply.

Read More
671 Words | 3 Pages

Throughout history different events have occurred that were considered immoral or inhuman, yet, the people committing to these activities were unaware of the situation itself and in their minds, were justified in their actions. This is also true when discussing slavery; pro-slavists defend slavery, arguing that slavery has existed since the pre-biblical era and it was the nature of mankind to have this hierarchy organize the modern world. Historical, pro-slavists argue that slavery has always existed additionally, they argue that slavery was God-ordained and therefore natural. Initially, historical justification is defined as always existing which in this case is true dating back to the “ancient republics of Greece and Rome and the great European empires” described by Foner (Foner, 406). A large party in the U.S. believed that holding slaves was morally wrong, however, since the bible stated that Abraham, the chosen servant of god, had servants similar to slaves working/living in the same

Read More
499 Words | 2 Pages

The Campus Activity Board usually sponsors and puts together bingo on the last Thursday of every month. On the night of October 26th from eight o’clock to nine o’clock they had bingo in the cafeteria as usual, and the big prize that night was an apple watch. I have not won anything so far in bingo, and that night was no exception. I was, however, one of the first three people standing for blackout bingo when we were trying to win the grand prize, and that was pretty cool. I did not think that bingo would be such a big event here on campus

Read More
1136 Words | 5 Pages

This is a tragic but expected consequence of a profit driven health care system, that people will make money off you and sometimes it will be a lot. In this conversation, David Kron

Read More
191 Words | 1 Pages

Clopidogrel (plavix) is an antiplatelet therapeutic agent belongs to the thienopyridines drug class of which necessitate metabolic conversion into the active drug by the cytochrome P450 (CYP) family of liver enzymes, primarily by CYP2C19 that inhibits the purinergic P2RY12 receptor selectively and irreversibly , and thus platelet aggregation. It is used to prevent heart attacks and strokes whereas it is considered as a treatment for Acute Syndrome of the Heart, Unpredictable Severe Constricting Chest Pain, Myocardial Reinfarction, Acute ST Elevation Myocardial Infarction,Peripheral Artery Thromboembolis. The drug is largely ( 85%) hydrolyzed to inactive forms by esterases whilst only about (15%) is tranformed to the active form by hepatic

Read More
1444 Words | 6 Pages

Pharmocovigilance Pharmocovigilance as define by the oxford dictionary is "the practice of monitoring the effects of medical drugs after they have been licensed for use especially in order to identify and evaluate previously unreported adverse reactions"[1]. In the EU all medicine is strictly analysed and tested for their quality , efficacy and safety before it is authorised for market. Even as these drugs are on the market they are continuously monitored to ensure any particulate which could affect the safety of the drug is identified and assessed and the necessary measures are taken .The Pharmocovigilance legislation was put into place to reduce the risks and increase the benefit of medicine and was "developed based on the observation that adverse drug reactions caused roughly 197,000 deaths in the EU"[2]. Since 1995 there have not been any major changes in the EU regulations of human medicine until the new Pharmocovigilance legislation came into effect during the month of July 2012.

Read More
1678 Words | 7 Pages

The cost of being sued, and the cost of malpractice insurance, greatly influences medical professionals (Braunstein, 2012). Healthcare costs in the United States are, in general, expensive. However, the cost of medical malpractice insurance coverage is becoming so expensive that they are starting to affect the practices of medicine. Due to this, many states have passed tort reform measures to limit the amounts rewarded to plaintiffs in medical malpractice suits (Hellinger & Encinosa, 2006). It is believed, by many in the medical profession, that limiting payments helps reduce the amount of malpractice claims.

Read More
1777 Words | 8 Pages

4. Abbott Vascular - Xience V 4.1 - Background Xience V is an everolimus-eluting stent that was FDA approved in 2007, and has since been considered the second generation of drug eluting stents. The backbone in Xience V (Figure 3) is a copolymer comprised of vinylidene fluoride and hexafluoropropylene [16]. The stent consists of a Multi-Link Vision cobalt chromium (CoCr), and is coated with the active component everolimus [6].

Read More
1081 Words | 5 Pages

A routine FDA inspection found at least 400 cases of fraud in patient enrollment. Despite knowing the fraudulent data, the FDA went ahead and presented it to the advisory committee for approval. It was voted 11-1 and passed; the known fraudulent data was never reported to the committee. Because of this false study, the drug stayed on market way longer than it should have. (Source E)

Read More
502 Words | 3 Pages

‘Many of them spend their life savings on cancer drugs and end up being bankrupt'" (Whitehead, NPR). With high prices on drugs, no one can afford to even survive. But the pharmaceuticals should consider that if the prices are too high, no one would and could be

Read More
744 Words | 3 Pages

Overall it can be concluded that we need to cure to coronary heart disease as it is also the disease which kills the amount of people under abusing diet pills in many countries. If we can stop taking these weight loss products or pills it will not only save millions of lives, but it will save billions of one particular country. I feel that if people knew a lilttle bit more about the disadvantages of diet pills they could coubter it before they realize they have it. Even you do lose weight by using diet pills, research suggests that once you stop taking the pills, you will gain back the weight and may be at greater risk of heat attack or stroke.

Read More

More about Praulent Research Paper

Open Document