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ST2: A Case Study

718 Words3 Pages

ST2 is a member of the interleukin-1 receptor (IL-1) family that exist as both a transmembrane ligand (ST2L) and a soluble, circulating form (sST2).35 ST2 can be measured from various matrices without substantial differences in results and can be measured with highly sensitive and precise methods with well-defined reference limits.36-38 It is applicable as a biomarker for HF , both acute and chronic, due to its dose-dependent expression as a result of cardiomyocyte stretch which is known to cause diastolic HF in humans as a result of hypertrophy. 39, 40 Elevated ST2 levels are also associated with ACS, but have not proven to be a reliable diagnostic marker for either HF or ACS. The same does not hold true for its prognostic value. For acute …show more content…

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