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Sacrosidase Study

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The objective is to characterize the dietary intakes of patients treated with sacrosidase for SID and determine relationships between type of carbohydrates, sacrosidase dose, and gastrointestinal symptoms. Forty-nine English-speaking patients treated with sacrosidase for > 3 months were recruited to participate in this 30-day observation study. Dietary energy and nutrient intakes reported during 24-hour diet recall interviews, frequency and severity of gastrointestinal (GI) symptoms, and Sacrosidase dose.

Energy intakes averaged 1,562.5+411.5 kcal/day in children, 1,964.7+823.6 kcal/day in adolescents, and 1,952.6+546.5 kcal/day in adults. Macronutrient composition averaged 44% carbohydrate, 39% fat, and 17% protein. Average carbohydrate composition …show more content…

It is conceivable that foods rich in potassium would be restricted by patients treated for SID due to their high starch or sucrose content. In addition to potassium, intakes of calcium, magnesium, and folate were also insufficient. It is likely that participants with lactose intolerance or those experiencing continued diarrhea were avoiding diary products, which may account for the insufficient intake of calcium.

Weakness: Some of the study’s limitations include a small sample size particularly when divided by life stage group. It is unclear whether the findings would differ in the case that participants were stratified by genetic diversity because current evidence has not confirmed that genetic diversity in SID produces phenotypic differences in intestinal function or gastrointestinal symptoms.

Boney, A., Elser , H. E., & Silver, H. J. (2017). Relationships among dietary intake and persistent gastrointestinal symptoms in patients receiving enzyme treatment for genetic sucrase-isomaltase deficiency. Journal of the Academy of Nutrition and Dietetics. Retrieved from http://jandonline.org/article/S2212-2672(17)31748-3/fulltext

El-Chammas, K., Williams, S. E., Miranda, A. (2017). Disaccharidase deficiencies in children with chronic abdominal pain. JPEN J Parenteral Enteral Nutrition. 41(3):463-469.

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