Starlings Forces

Starlings forces are the farces that control fluid filtration across the capillaries in the human body and can be described by the equation Jvol = Kf [(Pcap – Pint) – (cap – int)]. Starling’s forces are comprised of two major forces, the Hydrostatic force, or force generated by the fluid in the capillary or interstitial space, or the oncotic force, the force generated by proteins in the interstitial fluid or capillary. Forces that favor the filtration of fluids across the capillary membrane are Pcap, the force of fluids to move out of the capillary into interstitial space, and int, the force of fluids moving out of the interstitial space and into the capillary. Forces that oppose filtration across the capillary membrane are Pint, the force

Normal albumin concentration in the body ranges from 3.5-4.5g/dL, equaling a total body content of 300-500g of albumin, anything less than that is considered Hypoalbuminemic. Hypoalbuminemia can be caused by hepatic cirrhosis, or liver cirrhosis, resulting in a reduced synthesis of albumin because of healthy liver tissue is replaced by scar tissue. Since there is a low concentration of albumin and other proteins in the capillary, the starling’s forces of that capillary are disrupted. cap, the pressure in the capillary due to protein concentration, would be reduced because of the decreased amount of albumin in the capillary compared to the concentration in the interstitial fluid. Since there is a difference in protein concentration between the interstitial fluid and the capillary, Pcap would increase, causing increased fluid flow across the capillary membrane into the interstitial space to increase, leading to fluid accumulation and

Prolonged lymphatic obstruction can lead to Lymphedema, which is fluid accumulation and swelling in the tissues caused by the obstruction of vessels. Lymphatic obstruction could either be genetically inherited, in which lymph vessels are formed incorrectly resulting in dysfunction, or outside sources such as cancer or sugary which causes the removal or disruption of the vessels. This causes a disruption in the starling’s forces because fluid can be taken out of the capillary into the interstitial space, but it cannot reenter the capillary due to the blockage of the lymphatic