Now days, ultrasound has evolved to be the front runner of imaging modality for definitive diagnosis, planning of treatment, and therapy evaluation of patients with malignant and benign lesions. Diagnostic imaging studies must be able to detect malignancy in its early stages in order to achieve the best possible therapy outcomes. Nevertheless, conventional color Doppler technique suffers from technical limitations with-regard to visualizing fine vessels and low-velocity blood flow. While contrast-enhanced ultrasound (CEUS) increases the detectability of blood flow and thus is able to overcomes some of these limitations.