Tissue Engineering Research Paper

Shortage of cadavers and live donors have been escalating at an alarming rate. The various approaches for tackling the shortage of organs include increasing the live donor pool, accessing more deceased organs, expanding split donation, and paired donor exchange [REF29].These strategies follow standardized management systems, which guarantees efficient donation processes and split donation is not as successful as whole organ donation. The deceased organ source is mainly donation after brain death and donation after cardiac death is recently practiced [REF23].But organs donated after cardiac death is inferior in success rate. Paired exchange is another successful strategy for dealing with incompatible donor and recipient. A willing donor’s organ

It is an interdisciplinary approach wherein a combination of scaffold, tissue forming cells and growth factors works in coordination to facilitate the neogenesis of damaged tissue, the scaffold being biodegradable will gradually be replaced by the recapitulated tissue[7].A scientific meeting held in 1988 at Lake Tahoe, California, sponsored by the National Science Foundation,was the first meeting to discuss the significance of the field of Tissue engineering.The discussions in the meeting concluded by deriving a definition for TE ,which is cited as follows."Tissue engineering" is the application of the principles and methods of engineering and the life sciences toward the fundamental understanding of structure/function relationships in normal and pathological mammalian tissues and the development of biological substitutes to restore, maintain, or improve functions. This marked the birth of TE as a promising strategy for functional restoration of lost or damaged tissues. Follow-up discussions and meetings on this relatively new field dealing with “engineering living tissues” led to the inclusion of this term “Tissue Engineering “into the biomedical literature. Robert Langer and Joseph P. Vacanti were the pioneers in integrating all the findings related to this specific area and they defined TE as “Tissue engineering is an interdisciplinary field that applies the principles of engineering and the life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function” [Langer et al 1993].Thus Tissue Engineering can be defined as an integrative approach combining the principles of biological sciences and engineering, to create tissue or organ constructs that can functionally recuperate, sustain or reform damaged or lost tissue. The process involves guided regeneration of cells with temporary matrices and