ipl-logo

Wound Healing Research Paper

899 Words4 Pages

1. Wound healing process
Wound healing, a physiological response to the disruption in tissue integrity, is a dynamic and complex process imperative for maintaining homeostasis. It consists of four partially overlapping phases, namely the inflammatory, migratory, proliferative and maturation phase. Notably, this process is non-linear wherein it can advance and retract through the phases depending on various factors within the patients.
1.1 Inflammatory phase
Inflammatory phase can be further divided into hemostasis and inflammation, which is triggered immediately and last for about two to five days succeeding injury.
1.1.1 Hemostasis
Hemostasis, the process of stopping bleeding after an injury, involves three key processes, vasoconstriction, …show more content…

Specifically, inflammation begins when the inflammatory cells reach the wound and generally persists for several days. Upon injury, the resident mast cells undergo degranulation and secrete chemotactic agents that induce neutrophils recruitment. Furthermore, activated platelets also release proteins that stimulate the migration and adhesion of neutrophils and monocytes. Thus, the first inflammatory cells that infiltrate the wound are the neutrophils. These neutrophils, upon infiltration, first attach to the endothelium followed by undergoing diapedesis and migrate towards the area of inflammation. Subsequently, neutrophils release cytokines, growth factors and proteases to amplify inflammation reactions, promote cell proliferation and degrade extracellular matrix as well as debris respectively. Second inflammatory cells that enter the injured tissues are the mature macrophages differentiated from the circulating monocytes. Among other functions, activated macrophages phagocytosed microbes, foreign materials, apoptotic neutrophils and dying tissues from the wound in preparation for repair. They also synthesize a multitude of pro-inflammatory mediators and cytokines to trigger inflammation responses. Eventually, during the late inflammatory phase, T-lymphocytes enter the …show more content…

Within the first three days of wound repair, basic FGF from macrophages initiate angiogenesis and the subsequent injury–induced hypoxia stimulates the production of VEGF by epidermal cells followed, which sustained the angiogenesis stimulus for the next four days. Next, both plasmin and collagenase works synergistically to digest basement membranes so as to allow endothelial cells to migrate and form new blood vessels at the injured site. Once the wound is filled with new granulation tissue, angiogenesis ceases and many of the new blood vessels undergo apoptosis. On a similar note, there is continued growth of damage blood

Show More
Related
424 Words | 2 Pages

B and T cells help form a memory for your immune system.

Read More
517 Words | 3 Pages

Furthermore, he is also experiencing pain in the abdominal region due to a cut in the stomach, which is located within this area and he is also experiencing acid leaking from the stomach which may increase his pain to higher ranges. Additionally, the young adult is showing redness and swelling in the pelvic region due to internal bleeding and acid from the stomach being delivered there and accumulating within this area. The patient experienced homeostatic imbalance when the knife intersected his body. One of the first life functions that are being compromised in the patient is maintaining boundaries because due to the knife cut his internal body was exposed to the outside environment. The proximate life function that was compromised is digestion because his stomach has been damaged and his digestive system might not work in the proper manner at which it worked before the injury.

Read More
521 Words | 3 Pages

Then, antibiotics, surgery, anti-inflammatory agents, or obstetric procedures may regulate hemostasis, mainly in chronic DIC. However, in acute phase of DIC, two categories of treatment are available as follows: treatments that slow the coagulation process and therapies that substitute the coagulation factors and the missing platelets. Heparin also can be used to stop the uncontrolled stimulation of the coagulation cascade due to the antithrombotic properties. Careful monitoring of heparin is required because the heparin can worsen the bleeding. Red blood cell administration, thawed frozen plasma, and platelets transfusion may be use based on the patient

Read More
181 Words | 1 Pages

Mike has a torn cartilage in his shoulder due to excessive use while playing tennis so that means cartilage take longer time to heal because it has no blood supply or called avascular because it has no blood supply. It is also different with other different tissues such as skin, when it gets damage it can be recovered or healed because it received nutrition from foods. So Mike have not chance to recover is cartilage but it will be taking a longer time due to his cartilage shoulder because it has poor nutrition to receive from a body or cartilage can recover if they are children.

Read More
650 Words | 3 Pages

8.4 Discussion Diabetic patients often the wound heal poorly. They have higher incidence of DFU. Even if the patients have normal pulse rate the healing of wound and peripheral injuries are slow. The poor healing is diabetes is due to micro vascular change manifested by endothelial proliferation in small arteries and basement membrane thickening in capillaries. The obesity also leads to diabetes and reduces the immune capacity of the patient.

Read More
1371 Words | 6 Pages

Which cells are involved? White blood cells (macrophages, natural killer cells, neutrophils, mast cells, eosinophils and dendritic cells). Lymphocytes (B cells and T cells). Relation between exposure and immunological memory?

Read More
1227 Words | 5 Pages

Stage two is where the skin has a break or a tear, may be painful and red and have a blister or scrape like wound that penetrates below the surface of the skin. Stage three ulcers are ulcers that have progressed, a crater or opening deep into the tissue is usually noted fat maybe seen in this stage. Stage four ulcers are deep wounds that extend into the muscles, bones, and tendons, these are deep wounds and are painful and presents severe tissue damage. During stages three and four the risks for developing sepsis and osteomyelitis is increased due to the open wound leading to deep tissues. Unstageable wounds are just that, they cannot be staged usually due to the layers of dead/dying skin, pus, or infection skin covering the wound.

Read More
1173 Words | 5 Pages

Then there are also primary injuries and secondary injuries. Primary injuries are the injuries that happen right away (scientificamaerica). Then the secondary injuries are the injuries that could come later in life (scientificamerica). Physicians pay close attention to the secondary injuries because of the tissue damage (scientificamerica). Because secondary tissue effects are the beginning of long term effects like psychosocial changes, behavioral changes, emotional changes, bodily damage, brain damage, etc…

Read More
283 Words | 2 Pages

Innate immune system is recruited when C. diphtheria establishes infections. Neutrophils and macrophages recognize bacteria through the common molecular patterns on bacteria. C. diphtheria cells are engulfed and killed in the phagolysomes.

Read More
852 Words | 4 Pages

The previously mentioned biomarkers are mainly involved in this last stage of the wound healing process.

Read More
1024 Words | 5 Pages

This accelrated blood flow enables enables lymph to moved throughout the body more effeitnly than it normally does. Lymp is an immune system fluid that helps to gather and get rid of unwanted substances from the body. As such when lymph gets ciruclated throughout the body at a much faster rate, it essnetally boosts the immune system and makes it more cpapable of fighiing colds and

Read More
1520 Words | 7 Pages

However, Amulya K. Saxena the author of the article “Tissue engineering: Presents concepts and strategies,” states, “The advantage of this method is that it allows the graft to cover extremely large wounds; a disadvantage, however, is that 3-4 weeks are required for cell expansion.” Unfortunately until the cells fully expand and create new ones the victim must be in critical care. A more recent discovery involving stem cells has shown to be more promising, the Skin-cell Gun method. Essentially the Skin-cell gun shares the same concept as the skin graft, but without the long process of the graft’s forming, expansion, and the recovery rate, this process takes up to one to two hours to complete and its recovery time takes days rather than weeks.

Read More
745 Words | 3 Pages

1. As a child, you decide to ignore your mother’s advice and walk in a construction area bare-foot. To your chagrin, you step on a rusty nail and sustain a localized infection. Please describe, in detail, the immune response that develops (both innate and adaptive) after this injury. You may include flowcharts and sketches, if it is helpful.

Read More
1849 Words | 8 Pages

Professional Presence and Influence When we ponder: what is means to be human, surely most of us today think this question relates to our own humanity. Maybe the thought of being a living creature capable of not only basic functions like breathing and eating but of internalizing experiences, memories, complex problem solving and communication. Or perhaps it could touch on the fact that we “humans” are beings of blood, flesh, bone and energy that interacts between one another. A human is all of these and more. How this relates to healing is story long and old.

Read More
798 Words | 4 Pages

Inflammation may be acute or chronic. It is a result of a response to an injurious agent such as microbes and allergens. Inflammation also repairs or replaces tissue damaged by injurious agent. Signs of inflammation include tumour or swelling.

Read More

More about Wound Healing Research Paper

Related Topics

Open Document