Adrenergic receptor Essays

Homozygous, High Cholesterol Definition: Repatha is a monoclonal antibody to a Proprotein Convertase Subtilisin/kexin type 9 (PCSK9) inhibitors they work similarly to statins and the genetic and it has negative regulator of low density lipoprotein receptor (LDLR). Repatha is a medicine used to treat adults with primary hypercholesterolaemia with high blood cholesterol levels. Primary means that the disease is generally the result of a genetic abnormality and hypercholestrolaemia includes heterozygous

ST2 is a member of the interleukin-1 receptor (IL-1) family that exist as both a transmembrane ligand (ST2L) and a soluble, circulating form (sST2).35 ST2 can be measured from various matrices without substantial differences in results and can be measured with highly sensitive and precise methods with well-defined reference limits.36-38 It is applicable as a biomarker for HF , both acute and chronic, due to its dose-dependent expression as a result of cardiomyocyte stretch which is known to cause

and dynorphins, which both have effects on excitability, but with contrasting effects (11). The difference between these two peptides is that enkephalins bind to delta- and mu- opioid receptors (DORs and MORs) whereas dynorphins bind to kappa-opioid receptors (KORs). However, unlike galanin receptors, opioid receptors can be activated by exogenous opiate drugs, which means that overdose can be possible because it is not reliant on an endogenous ligand. For example, the MOR agonist morphine can bind

Society has no idea how fast things are moving and changing, with that comes a world of foreign knowledge and shock towards what is to come. When a person sees another human with very dark skin no one thinks “Is that a genetically modified superhuman?” well, hopefully most citizens do not. Because people from Africa live under such harsh sunlight the radiation can become very detrimental to the skin. Over years the Africans have had the melanin in their skin become significantly darker in order to

In his short story, “The Blue Hotel,” celebrated American novelist, Stephen Crane, delivers an intriguing tale concerning a group of men who take refuge in a Nebraskan hotel during a blizzard in the 1800’s. Whilst at the hotel, one of the men referred to as “The Swede” takes an eccentric turn which leads to a brutal fight between himself and the proprietor's son, stemming from a quarrel over a card game. This confrontation inadvertently leads to the Swedes death in a local saloon. While the plot

A good man is hard to find is about a family who are planning to travel to Florida. The whole family is excited to go except the grandmother, who doesn’t want to go. To make her case, she tells her son Bailey, his wife, and their three children that there’s a criminal named the Misfit headed to Florida. The Misfit is one of the main characters in the story. The author, Flannery O’Connor, introduces him explaining his background and motivations. In doing so, she portrays a character that is both mythical

2 examples of each When the action of the drug is to activate or switch on a reaction, the drug is called an agonist. On the other hand, if the drug switches off the reaction, or inhibits or blocks the binding of other agonist components onto the receptor, it is called an antagonist. Hence, agonist and antagonist act in opposite direction, if agonist activate an action, antagonist inhibit an action(New Health Guide, 2014).Besides, agonist is imitates the action of neurotransmitter, but antagonist

“In Aristotelian terms, the good leader must have ethos, pathos and logos. The ethos is his moral character, the source of his ability to persuade. The pathos is his ability to touch feelings to move people emotionally. The logos is his ability to give solid reasons for an action, to move people intellectually,” said Mortimer Adler. Many of the greatest artists use ethical, logical, and emotional appeals to prove their points. Eric Schlosser uses various ethical appeals in Fast Food Nation. Michael

Throughout my life adversity has always been present. Within my family alone I have struggled a lot with different health issues that have been affecting me since day one. Although some people may think of this as a negative thing in my life, I believe it to be positive because of the way that it has brought my family closer together. Since I was born all I have ever known was blood tester strips hiding in every spot in our house and car, the smell of insulin, and the familiar clunking of a dialysis

MODAFINIL:DRUG OF THE MODERN ERA Modafinil(commonly known by the brand names Provigil, Alertec, Modavigil etc) is an oral drug that is used to induce wakefulness in patients with sleepiness. It reduces fatigue and enhances alertness in an individual. It is also known as nootropic. It is usually taken once in a day with or without eating your meal. Modafinil is approved by the U.S. Food and Drug Administration for the treatment of narcolepsy or Obstructive sleep apnea hyperpnoea syndrome (OSAHS)

Should cigarettes be illegal? Should smoking be illegal? Yes, you may ask yourself why? Simply because it results in a large number of death’s (the most in the uk to be precise).Most of us aren’t aware of the side effects from smoking cigarettes, which is very worrying to me. According to the NHS, its estimated that over 120,000 deaths are caused by smoking annually. All those cigarettes that you smoke then leads to horrible effects later in life; e.g. Cancer, Brain Damage, high blood pressure,

Introduction The Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disease. It is characterised by muscle weakness of the proximal lower limbs as a result of auto-antibodies produced against the voltage-gated calcium channels (VGCC) found on the presynaptic membrane of the neuromuscular junction(1). Most of the time, LEMS is classified as a paraneoplastic syndrome as it is often associated with cancer (small cell lung cancer in particular) (2, 3). One of the earliest descriptions of this

From the 1990’s movie entitled Awakenings directed by Penny Marshall. A sprung of hope has happened to people who suffered the post-effect of the 1920’s epidemic disease called Encephalitis Lethargica by bringing them back to their mobile bodies for a limited time by the neurologist, Dr. Malcolm Sayer. Encephalitis Lethargica, also known as sleeping sickness, is viral epidemic encephalitis that occurred between 1915 and 1926 and those who survived the initial infection displayed long-term apathy

Ach is used by the parasympathetic nervous system to activate muscarinic and nicotine receptors and can each preferentially interact one of the two types of receptors. Atropine specificity is it action to act as the antagonist of acetylcholine (ACh), inhibiting the muscarinic actions of ACh on the structures innervated by the vagus nerve. 3. What type of antagonism does atropine display at the muscarinic receptor? What is meant by EC50? Describe the change to EC50 in your experiment in the presence

Home LGD 4033 (Ligandrol) is a selective androgen receptor modulator (SARM) that is a much safer alternative for building muscle mass without all of the dangerous side effects. It works so effectively that some people are able to gain as much as 1-2 pounds of muscle in a week when they increase the amount of protein that they eat and continue their regular workouts while taking it. Though Ligandrol is considered to be one of the strongest muscle builders on the market, supplements containing Ostarine

1. What does Sue need to know about herself to determine how she will make decisions about providing care for indigent persons? Pg 228 Sue needs to address many aspects of intrapersonal biases that every individual has about the relationship they might have when dealing with indigent patients. Sue needs to identify and set aside any personal bias about what she feels is right for the patient without taking into consideration if it correlates with the autonomy of the patient to make their own health

bipolar disorder. Therapy for acute manic episodes includes initiation of a mood stabilizer like lithium as well as an atypical antipsychotic such as risperidone. Risperidone decreases positive symptoms like mania by inhibiting D2 dopamine receptors. D2 receptors in the mesolimbic pathway are thought to be responsible for psychotic episodes. Choice "A" is not the best answer. Acetylcholine is a neurotransmitter at the neuromuscular junction and also a neurotransmitter in the autonomic nervous system

In heart failure, beta-1 receptor is down regulated, while beta-2 receptor is uncoupled from post-receptor event. The benefit of beta blockers depends on blocking beta-1 receptor. Beta-blockers in general antagonize the effect of catecholamines, resulting in negative chronotropic effect and negative inotropic effect. Possible mechanisms for beta blockers

care 100 μg/ml). It can also be used for intrathecal and epidural anaesthesia. MECHANISM OF ACTION OF DEXMEDETOMIDINE Dexmedetomidine is the dextro enantiomer of medetomidine, the methylated derivative of etomidine, its specificity for the alpha-2 receptor is 8times that of clonidine, with an alpha-2/alpha-1 binding affinity ratio of 1620:1 & its effects are dose dependently reversed by

Basic pharmacology of agent used in the treatment of asthma Pharmacodynamics about Salbutamol (INN) or albuterol (USAN), a moderately selective beta (2)-receptor agonist similar in structure to terbutaline, is widely used as a bronchodilator to manage asthma and other chronic obstructive airway diseases. The R-isomer, levalbuterol, is responsible for bronchodilation while the S-isomer increases bronchial reactivity. The R-enantiomer is sold in its pure form as Levalbuterol. The manufacturer of levalbuterol