when they need to make other compounds such as the alcohol (Crabtree pg 253). The reagents used during the Grignard reactions are called the Grignard reagents or generally as the organomagnesium halide. For the effective Grignard reaction to take place, an addition to a ketone or the usage of aldehyde in the reaction to any of the tertiary or secondary alcohol has to take place (Seyferth pg 432). Grignard reagents are often made through the reaction of the halogenoalkane with small amount of the
Kolbe-Schmitt Reaction Kira Wall (CHE433) 12-3-14 The Kolbe-Schmitt reaction is named after Hermann Kolbe and Rudolf Schmitt. Schmitt published his research in the Journal fur Pracktische Chemie in 1885 while Kolbe published his research in the Annalen der Chemie und Pharmacie in 1860. The reaction adds a carboxyl group onto the benzene ring of a phenol. The process uses a base carbon dioxide and acid work-up. The original reaction done by Kolbe involved the formation of sodium phenoxide
Grignard is a reaction that is crucial to forming the new carbon-carbon bond. This is a two-part lab that teaches new techniques; the purpose of this lab is to introduce realistic organic synthesis and apply acid workup to produce triphenylmethanol. A Grignard reaction is characterized by the addition of a magnesium halide (an organomagnesium halide) to an aldehyde or a ketone in order to form a secondary or tertiary alcohol. These reactions are helpful because they serve as a crucial tool in performing
between a Grignard reagent and an aldehyde leads to the production of a secondary alcohol. In fact, this is what we observed with regards to the experiment results. The addition reaction between the Grignard reagent, phenolmagnesium bromide, and benzaldehyde leads to the formation of diphenylmethanol, a secondary alcohol, as the product. As mentioned earlier, the reaction of the alkyl halide, bomobenzene, and magnesium metal turnings leads to the production of the Grignard reagent. This was observed
Samarium (II) Iodide A single electron transfer reagent useful for organic synthesis. A look into samarium (II) Iodide (Sml2), a powerful single electron donor which plays a vital role in the chemoselective reduction of certain functional groups and carbon-carbon bond formations. Cathal McKenna Student Number: 11322441 10/6/2014 Introduction Samarium (II) Iodide has emerged in recent times as a very useful reagent in organic synthesis. The compound was first used by Kagan and his researchers
I first met my friend in Calculus 2 in my sophomore year. His major was biochemistry, just like mine, so we ended up taking other classes together. In General Chemistry 2 lab, we were lab partners. We helped each other out on the long and tedious process of writing lab reports. The Organic Chemistry 1 lab was a little better, but still long with many failures and repeats of experiments. Despite the struggles, we had fun in the lab too, like in the experiment where we had to extract the fragrance
from the 1800’s. Dr. Wöhler was alive in a period where chemistry was separated into two different areas; Organic Compounds and Inorganic Compounds. At the time, Organic compounds (chemicals generally derived from plants or animals) were viewed as less stable, and formulas were difficult to ascertain from elemental analysis. Whereas, Inorganic Compounds were easier to “deal with” scientifically. Inorganic Compounds followed the laws of chemistry and were easy to synthesize and analyze. (Ramberg, 2000)
interest in chemistry and was fascinated by its connection to every aspect of our daily life. This curiosity started during my early middle school days while sitting in a summer teacher quality chemistry class taught by my mother. Although I did not have the background and capability to understand the content at the time, the demonstrations, videos and activities deepened my interest in chemistry. During my junior year in high school, when I first took a chemistry course, my admiration for chemistry started
Introduction Chemical synthesis is the process of making complex compounds from other compounds. This technique is important because it allows chemists to make compounds that may be expensive or rare by using inexpensive or abundant starting compounds. Some of these syntheses take several steps to get to the end product, these being multistep syntheses (Reusch, 2013). A multistep synthesis has several factors that should be considered. These include: selectivity, acidity, basicity, and reactivity
Somalie Prak LIBS 4960 Dr. Katie Olivant Chemistry Chemistry is a study of fundamentals of inorganic chemistry. This course is designed to provide you with basic understanding of chemistry and prepare you for more advanced chemistry courses. One concept that I learned in this course was the Atomic Theory. This theory suggests that all matter is made up of tiny indivisible particles that are called atoms. Atoms can be defined as the basic unit of a chemical element or the basic building blocks of
Career Exploration Fields: Organic chemistry is the study of carbon-based molecules. These chemists are called organic chemists and work with substances found in living things, such as plant and animal material. Modern organic chemists, however, have expanded the field to also encompass non-organic compounds. Not only do they transform organic compounds into new compounds not found in nature, they also synthesize non-organic compounds into synthetic organic compounds by separating molecules and
Endless numbers of extraordinary content and theories in chemistry continue to interest me and have fuelled me to research further into my current studies in addition to extra-curricular reading around the subject. Chemistry holds many unique qualities; for example the ability to calculate the number of particles of air present in any room given the room volume and standard conditions. I personally find this hugely intriguing especially with the knowledge that there are likely to be approximately
History of Glyphosate Commercial Use Glyphosate is a white crystal-like powder with the chemical formula of C3H8NO5P. Several researchers confirmed that glyphosate was synthesized in 1950 by Henri Martin who was working for a pharmaceutical company at that time (Alibhai and Stallings, 2001; American Chemical Society, 2010; Dill et al., 2010). In a separate research work conducted by the Monsanto Company, the chemists were able to discover two glyphosate-related chemicals that have weak herbicidal
In the main quadrangle, I struck up a conversation with a UChicago student. When I asked him what he was majoring in, he said with a completely straight face, “Religious Studies and Astrophysics”. While other institutions might satisfy one of my interests, UChicago can satiate them all. I’ve always been curious, which unquestionably translated into a love for discovery. Instead of wanting dolls for my birthdays, I asked for Legos or 1000-piece jigsaw puzzles. Walking through Best Buy, I’ve always
Hi Dad How is it going? My first semester at the University of Michigan is very exciting. One of my favorite classes is the organic chemistry lab. It is completely different from the typical Orgo lab that you took at college. The instructors are trying to teach us the applications of chemistry in real life. Indeed, we, as students, are even creating our own experiment and testing our own hypothesis. This week, my group’s experimental goal was to convert an inactive prodruge to an active drug. You
During my junior year of high school I was taught general chemistry for the first time. My interest for molecules, compounds, and their bonds spurred through my involvement in Chemistry and Biology. After completing these courses my motivation to pursue a career in Chemistry increased. Thus my decision became certain, and I applied to University under the Science Department. In addition to the course that awakened my interest, I sought to involve myself in volunteer opportunities, one of which involved
Chemistry Exploration Topic: determining the activation energy of a chemical reaction Research Question: What effect does temperature of the chemical reaction have on the activation energy ? ICT: Microsoft Word Autograph Microsoft Excel Introduction This experiment is designed to help in estimating the activation energy of the rate-limiting step in the acid catalyzed reaction of acetone with iodine. This is achieved by measuring the reaction rates at different reaction temperatures over
Lab Report 10: Nitration of Bromobenzene Raekwon Filmore CM 244 Section 40 March 27, 2018 Introduction: For this experiment, nitration of bromobenzene was the focus of the lab. The benzene is an aromatic compound and when it reacts with wither a mixture of sulfuric acid or nitric acid creates what is known as a nitro group. The formation of the nitro group is possible because it is an electrophilic aromatic substitution reaction. The creation of the nitronium ion is shown below: The reaction
Dr. Condeiu’s presentation on synthetic organic chemistry was a rewarding experience because he touched on some very important concepts. Not only did he mention many of the things discussed in class in terms of real world examples, but he also brought a human face to being a synthetic organic chemist, and also mentioned several examples of synthetic challenges he has personally faced. Dr. Condeiu showed some real life examples of themes we discussed in class. In particular, I found his example
In the talk, “Adventures in Organic Chemistry – Over Three Decades of Synthetic Organic Chemistry” presented by Dr. Chris Condeiu, he tried to relate the industry of organic chemistry to a students’ perspective. Three major points were drawn out through the talk. The first was the perspective of how capitalism drives the industry and the mechanism of doxycycline was formed. With an overview of his talk, the expectation was that a deeper understanding of how pharmaceutical drugs’ mechanisms are formed;