C4564 Description: IC50: 3-AP is a ribonucleotide reductase inhibitor and iron chelator with antitumor activity. Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is an excellent target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation.
All the fundamental vibrations are IR active stable structure. The harmonic vibrational frequencies calculated for doped fullerene with glycine have been compared from low frequency (below 1000 cm-1) to high vibrational frequency (above 1000cm-1) as shown in Table5. The symmetrical stretching vibrations of NH2 group are assigned in 3079, 3569 and 3613cm-1. The two strong stretching vibrations are found at 3569, 3695cm-1 for doped fullerene C19Si-glycine and 3569, 3715cm-1 for C19Ge-glycine. The strongest carbonyl stretching, vibration peak at 1769cm-1for doped fullerene interacting with amino acid C19Si-glycine and at 1780cm-1 for doped fullerene C19Ge-glycine peak are presented in Fig 7.
The lab started off by measuring critical materials for the lab: the mass of an an empty 100 mL beaker, mass of beaker and copper chloride together(52.30 g), and the mass of three iron nails(2.73 g). The goal of this experiment is to determine the number of moles of copper and iron that would be produced in the reaction of iron and copper(II) chloride, the ratio of moles of iron to moles of copper, and the percent yield of copper produced. 2.00 grams of copper(II) chloride was added in the beaker to mix with 15 mL of distilled water. Then, three dry nails are placed in the copper(II) chloride solution for approximately 25 minutes. The three nails have to be scraped clean by sandpaper to make the surface of the nail shiny; if the nails are not clean, then some unknown substances might accidentally mix into the reaction and cause variations of the result.
K.D.A. Saboia et al. , (2007) have been prepared the Bi4Ti3O12–CaCu3Ti4O12 {[BIT(X)–CCTO(100-X)]} composite powders through solid state reaction method and calcined in the range of 900 to 1020 ºC for 12 h. The as-prepared powders have modified in the form of thick film onto alumina ceramic substrate by utilizing screen printing. At 100 Hz, the value of dielectric constant (κ) of CCTO100 and BIT100 is 316.61 and 53.64 respectively. Conversely, the composite with X=20 % shows an unexpected dielectric constant of 409.71, which is around 20% higher in comparison with the CCTO.
Firstly, intermolecular forces and strengths of different chemical substances could be identified using valence shell electron pair repulsion shapes and prior knowledge of various kinds of intermolecular forces: London Dispersion, Dipole-Dipole, and Hydrogen bonding. Knowing this, Acetone was seen to possess London Dispersion and Dipole-Dipole forces. Propanol was seen to possess London Dispersion, Dip0le-Dipole forces, and Hydrogen Bonding. Acetic Acid was seen to possess Hydrogen Bonding and Dipole-Dipole forces. Overall,
Dehydration of 2-Methylcyclohexanol Sura Abedali Wednesday 2:00 PM January 31, 2018 Introduction: Dehydration reactions are important processes to convert alcohols into alkenes. It is a type of elimination reaction that removes an “-OH” group from one carbon molecule and a hydrogen from a neighboring carbon, thus releasing them as a water molecule (H2O) and forming a pi bond between the two carbons1. In this experiment, 2-methylcyclohexanol undergoes dehydration to form three possible products: methylenecylcohexane, 1-methylcyclohexene, and 3-methylcyclohexene in a Hickman still apparatus. Adding 85% Phosphoric Acid to protonates the “-OH” group, turning it into a better leaving group and initiating the dehydration reaction.
The goal of the experiment is to synthesize a bromohexane compound from 1-hexene and HBr(aq) under reflux conditions and use the silver nitrate and sodium iodide tests to determine if the product is a primary or secondary hydrocarbon. The heterogeneous reaction mixture contains 1-hexene, 48% HBr(aq), and tetrabutylammonium bromide and was heated to under reflux conditions. Heating under reflux means that the reaction mixture is heated at its boiling point so that the reaction can proceed at a faster rate. The attached reflux condenser allows volatile substances to return to the reaction flask so that no material is lost. Since alkenes are immiscible with concentrated HBr, tetrabutylammonium bromide is used as a phase-transfer catalyst.
ST Report In the experiment, the problem was the contaminants that were affecting the quality of the water samples. To fix this issue, three scientists had to determine the contaminants that were present in the samples. One sample was from the school sink and the second sample was from an unknown source. The scientists conducted many tests to figure out what pollutants were present in the water.
The materials and methods used in this experiment are as written from the Laboratory Supplement of David L. Shultz. To properly prepare for the experiment, the materials needed were one stoppered shell vial or small Erlenmeyer flask for flies, seventy flesh flies (Sarcophaga bullata, ice-cold to anesthetize them), one wire test-tube rack (small mesh), a few paper towels to cut the flies on, one razor blade, one enamel pan, one thermometer, one grease pencil, one piece of plastic wrap, one large plastic beaker filled with crushed ice, seven large glass test tubes to hold reagents, homogenate, and centrifuged fractions, seven glass reaction tubes (small size, about three inches tall), and seven plastic pipettes (one milliliter and controls). When all
Synthesis, molecular modeling and bio-evaluation of cycloalkyl fused 2-aminopyrimidines as antitubercular & antidiabetic agents 1. Introduction: o The target name and type: The target in this paper is the mycobacterial di-hydro folate reductase, alpha-glocosidase and glycogen phosphorylase The type of the targets is enzymes. o Diseases that associated with the target:
Efficacy of topical cyclosporine 0.05% eye drops in the treatment of dry eyes Haitham Y. Al-Nashar J Egypt Ophthalmol Soc 108:233?236 Purpose: The aim of the present study was to detect the effectiveness of cyclosporine 0.05% eyedrops for treatment of patients with dry-eye disease. Patients and methods: A total of 35 eyes of 20 dry-eye patients were included in the present study.
Introduction Strong acids and strong acids both dissociate completely in water forming ions. However, strong acids donate a proton to form H3O+ along with a conjugate base and strong bases accept a proton to form OH- along with a conjugate acid. The chemical behavior of acids and bases are opposite. When they are together, their ions cancel out and form a neutral solution. In this experiment, HCl and NaOH will react to form NaOH and H2O with these two steps: The overall reaction is: Both Na+ and Cl- ions combine to form NaCl.
Hydrogen chloride has a very powerful smell. It is in the form of a gas but only when it is at room temperature which is approximately 25 Celsius and when the pressure is high. When you add water to hydrogen chloride then it breaks down into small pieces which are known as dissolving. The solubility of hydrogen chloride is very high this means that it can dissolve in water quickly because it dissolves many times in its own solution (the gas form of hydrogen chloride). It is very soluble because the smaller the chain of the molecules are then the energy will be required in small quantities however if the chain is long then it will need more energy
Introduction Chevron Phillips Chemical Company is the major producer of Cyclohexane. This successful company hoses the three largest cyclohexane plants in the world. Many are puzzled by how the production of cyclohexane seems to have become stagnant. Perhaps this is due to the cost of benzene increasing or the demand increasing. Through thorough investigation, the answer to this question and many more can be answered.
Abstract The unknown concentration of benzoic acid used when titrated with standardized 0.1031M NaOH and the solubility was calculated at two different temperatures (20◦C and 30◦C). With the aid of the Van’t Hoff equation, the enthalpy of solution of benzoic acid at those temperatures was determined as 10.82 KJ. This compares well with the value of 10.27KJ found in the literature.
