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Omalizumab Research Paper

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Omalizumab
Omalizumab is a humanized monoclonal antibody used for the treatment of persistent allergic asthma. In general, allergic reactions are triggered by IgE present in human immune system. Allergies predominately occur on skin surface, in gut, in respiratory tract, or any other sites of parasitic invasion. The persistent allergic asthma is the allergic reaction at the respiratory tract that initiates inflammation, bronchoconstriction and mucus secretion. Omalizumab binds to the Cε3 domain of IgE and forms hexamer complex that inhibits the immune response by preventing IgE from attaching to mast cells and other effector cells, thus down-regulating the FcεRI receptors (see Appendix for more information).

Genentech, Inc., a U.S. subsidiary …show more content…

As a result, FDA has added information about these potential risks to the drug label. The review also found that there is no difference in the rates of cancer between those patients being treated with Xolair and those who were not being treated with Xolair. However, due to limitations of 5-year study in analyzing the cancer rates associated with Xolair, FDA is currently not in the state of ruling out the potential risk of cancer with this drug. So this information was also added to the Warnings and Precautions section of the drug label. These current events are said to be the major drawbacks in Xolair manufacturing …show more content…

(2003). Asthma, Rhinitis, Other Respiratory Diseases: Brief Communication: Omalizumab, a recombinant humanized anti-IgE antibody, reduces asthma-related emergency room visits and hospitalizations in patients with allergic asthma. The Journal of Allergy And Clinical Immunology, 11(1), 87-90. doi:10.1067/mai.2003.49
D'Amato, G., Stanziola, A., Sanduzzi, A., Liccardi, G., Salzillo, A., Vitale, C., & ... D'Amato, M. (2014). Treating severe allergic asthma with anti-IgE monoclonal antibody (omalizumab): a review. Multidisciplinary Respiratory Medicine, 9(1), 23. doi:10.1186/2049-6958-9-23
Omalizumab- Mechanism of action [Online Image]. Aspergillus & Aspergillosis Website. Retrieved from http://www.aspergillus.org.uk/content/omalizumab-new-treatment-option-allergic-bronchopulmonary-aspergillosis-abpa
Ruffin, C. G., & Busch, B. E. (2004). Omalizumab:A recombinant humanized anti-IgE antibody for allergic asthma. American Journal of Health-System Pharmacy, 61(14), 1449-1459.Retrived from http://www.medscape.com/viewarticle/483809_2
Xolair - Biological Therapy (2015). Drugdevelopment-Technology. Retreived from http://www.drugdevelopment-technology.com/projects/xolair/

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