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Pros And Cons Of 1918 Pandemic

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The 1918 influenza pandemic had a significant impact across the globe due to its unusual virulence and ability to affect healthy adults, influencing its high death toll. Recreating the 1918 pandemic virus poses pros and cons that are increasingly relevant in the context of the COVID-19 pandemic and the increased public scrutiny of ‘gain-of-function’ research. Essentially, any information is beneficial in the ‘right hands’ but can be dangerous in the ‘wrong hands.’ Sequencing the 1918 virus provided insights into its emergence and genetic features contributing to its exceptional virulence that drove the pandemic’s impact. However, researchers noted that sequencing was insufficient to explain the virulence. Reconstruction of the virus allowed …show more content…

Additionally, differences from other human flu viruses in all genome segments provided strong evidence for an avian origin rather than human and avian virus reassortment. The identification of mutations facilitating the species jump in the reconstructed 1918 virus is critical for surveillance of potential pandemic bird viruses, which has already been validated by the presence of such mutations in H7N7 which was able to infect humans. The discovery of accessory protein PA-X's role in modulating the host immune response and pathogenesis was also enabled by reconstructed virus, contributing to the understanding of influenza biology and potential antiviral targets. Sequence information is not sufficient to analyze the impact of treatment strategies. Therefore, modern prophylactic and therapeutic strategies could be tested against the recreated virus to inform their effectiveness against future strains with similar virulence and pathogenic features. Reconstructing the 1918 virus was beneficial in identifying the genetic characteristics of its virulence and factors affecting its pathogenicity as well as identifying effective drugs and

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(Mayo Clinic) I read an astonishing research topic on "Mapping Flu 's Trek Through Our Cells" http://www.niaid.nih.gov/topics/Flu/Research/Pages/mappingFlu.aspx It clarified how a team did medical research on more than 19,000 human genes to screen to see what genes the virus could not do without. Our bodies actually help aid the influenza virus make more of itself. (National Institute of Allergy and Infectious Diseases) After reading the article you posted, as well as numerous others, it just confirms the logic why my family does not receive the vaccine for the flu.

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The Influenza Pandemic of 1918 was a tragic event in the history of the United States. The illness struck the globe. The flu killed over 675,000 people. The Spanish flu, despite its name, originated in the state of Kansas. The flu itself originates from a bird and spreads rapidly with common flu-like symptoms.

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