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What Is The Importance Of Alzheimer's Study In 100 Years Of Solitude

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Famous Colombian writer Gabriel Garcia Marquez’s novel, 100 Years of Solitude, tells of a family who are all suffering from a strange affliction that erases their memories. While it is unlikely that Garcia Marquez realized it, his art was indeed ‘imitating life. Gabriel Garcia Marquez is among the most acclaimed Colombian authors of all time and is heralded in the literary genre of magical realism, yet the life of those in the Antioquia region of Colombia cannot escape the affliction that plagues their literature and families. Antioquia was previously only notable for being the murder capital of the world, but it is now being deemed ‘The Alzheimer’s Laboratory,’ due to it being a perfect research opportunity, as it houses the largest concentration …show more content…

First, it is important to know what this study is testing for; the study in Antioquia is different from any other Alzheimer’s study, as stated by the National Institute of Health, because the Paisa mutation that causes the early-onset Alzheimer’s that the Antioquians suffer from, is testable through blood samples. This means that for the first time, we can diagnose Alzheimer’s before the symptoms show. So since Genentech has created, and is testing an immunotherapy drug on people that are definitely going to develop the disease, it can be seen whether or not the presence of the beta-amyloid plaques, which are largely believed to cause the dementia, are altered or are alterable. Everyday Health reports that in this study there are 300 participants who would be 5 years away from symptoms beginning to show. Of these 300, only 100 will get the trial version of the immunotherapy drug. The remaining will be given a placebo. It is what is called a ‘double-blind’ trial, where neither the administrators of the drug, or the recipients, know who is going to have the disease, get the placebo, or not. According to Dr. Kosik, this double-blind aspect of the study is by choice, and can be considered more humane, as there is currently no definite help for those who are to be afflicted by the

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Likewise, the best treatment should not refer to local treatment standards, but the best standards available to maximize the beneficence and justice applied to participants already undertaking the burden of participating in a clinical trial. Unfortunately, ethical principles can sometimes be neglected due to competition in the field and the increase of regulations. This has resulted in some ethically questionable trials based in third world countries that violate justice, autonomy, and beneficence to obtain faster results. Harold Varmus and David Satcher’s perspective on what standards and guidelines should be implemented in clinical trials in third world countries differs from that of Angell’s arguments. They make the argument that compared to other approaches, a placebo is the most justified way to obtain clear and rapid results from clinical trials regardless of what treatments may currently be available.

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In Chronicle of a Death Foretold, written by Gabriel Garcia Marquez, Marquez incorporates the culture of Colombia with a focus on three ideas that were prevalent during the 1950’s: the stress placed on women to be pure for marriage, the concept of machismo, and the importance family honor. Marquez presents these aspects of Colombian culture as an epitome of a flawed way of thinking, because ultimately this ideology ends with murder. Marques critiques the gender role women take, by focusing on their need to be pure for marriage, and the way that men dominate, and control them in family life. Marquez also rebukes the concept of machismo and the importance of honor, by having these justify the murder of Santiago Nasar.

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