Pathophysiology of Hematuria
Throughout the process of filtration by the kidneys, along with the help of the ureters, the bladder and urethral to expel urine from the body, there are many possibilities that abnormalities can develop that could compromise the healthy characteristics of the filtration process. Hematuria, for example, is the irregular presence of red blood cells in the urine due to dissected variations of trauma in the urinary tract. There are two types of causes of hematuria, the glomerular and nonglomerular cause. The glomerular cause is trauma within the nephrons of the kidneys, where red blood cells enter the urine stream from the glomerulus. The glomerular capillary walls are at risk for bleeding when there is a massive disruption in the process of filtration by the kidneys. This condition can be supported if the urine also contains protein (proteinuria), alarming the people that blood loss is from the glomerulus not outside the glomerulus. On the other hand, the nonglomerular cause is associated by extraglomerular, or outside the glomerulus capillary walls, bleeding. This bleeding can sometimes be a normal reaction when there is irritation, inflammation, or invasion of the epithelia
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However, in other situations extraglomerular bleeding can be caused by renal stones, severe trauma, infection, medications, and even cancer throughout urinary system, such as bladder cancer