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Cns Lymphoma Research Paper

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Lymphatic cancer, or Lymphoma is a type of malignant cancer culpable of afflicting approximately 332,000 Americans each year. Lymphoma is distinguishable by the uncontrolled growth of lymphatic cells known as lymphocytes. A type of Lymphatic cancer is Central Nervous System Lymphoma, or simply CNS lymphoma. CNS lymphoma can be described as a form of non-Hodgkin lymphoma, which is characterized by the invasion of cancerous lymphocytes into the central nervous system. Once malignant cells invade the central nervous system severe damage can occur. The structures affected by CNS lymphoma are the brain, spinal cord, and the eyes. CNS lymphoma is only one example of how malignant cells in the lymphatic system can lead to other life threatening cancers …show more content…

In order to sustain the body’s function lymphocytes have the ability to travel throughout the entire body, through lymph vessles and the blood stream, allowing cancerous cells various paths into organs to metastasize. The specific type of cell involved in CNS Lymphoma is the B-cell. B-cells are a form of white blood cell responsible for the secretion of antibodies. B-cells develop from hematopoietic stem cells, a cell manufactured in the bone marrow of humans. The central Nervous System is comprised of the brain and spinal cord. The lymphatic system and the organs involved in the system perform multiple functions interrelated to the overall function of the body. It is responsible for the transportation of lymphocytes, and the distribution of fluids and fats. However, a system with vessels and an entire bloodstream used to access all parts of the body is extremely vulnerable to an invasive cancer such as …show more content…

Non-Hodgkin Lymphoma can originate in any organ throughout the lymphatic system, such as the liver, Spleen, thymus, and tonsils. Each organ involved in the lymphatic system produces lymphocytes, or white blood cells, which make CNS Lymphomas common among immunodeficient patients, or patients with AIDs and HIV; patients who suffer from autoimmune diseases. These factors greatly influence a patients prognosis as well. Central Nerous system Lymphoma is an aggressive cancer, therefore the prognosis for those afflicted is low. The age, and general health of a patient afflicted with CNS lymphoma affect their ability to fight the cancer. Location and if the patient has AIDs as well, will also determine the prognosis of a patient. As a result, according to cancer.gov, 2 to 3% of people with AIDs have some form of non- Hodgkin related lymphoma. Once malignant cells migrate into the Central nervous system the tissues become inflamed and

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As a result, these cells form a clump that is commonly referred to as a tumor (neoplasm), especially when the immune system is malfunctioning. Tumors can be benign, harmless and easily taken out or malignant. Malignant tumors block tissues and organs from functioning with each other. Once cancer cells become metastasized, they break away from a host tumor. These free-floating

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Lymphoma comprises a histologically heterogeneous group of cancers arise from the cells of the immune system with enlargement and propagation of lymph nodes or secondary lymphoid tissues.(1). " About 54 percent of the blood cancers that occur each year are types of lymphomas", The main types of lymphomas are Hodgkin lymphoma and non-Hodgkin lymphoma. non-Hodgkin lymphoma is a cancer that starts in cells called lymphocytes , which are part of the body’s immune system. There is different signs and symptoms can caused Non-Hodgkin lymphoma , it depending on where it is in the body for example: Fever, Weight loss, Night sweats, extreme tiredness ,anemia , Enlarged lymph nodes, Swollen abdomen (belly), Feeling full after only a small amount

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Non Hodgkin Lymphoma is the most frequently known forms of cancer that originates in the Lymphatic System. This disease is also known to be the sixth leading cause of death in Lymphoma patients in the United States. The Lymphatic System consists of lymph nodes that are found in certain organs and areas of the body. Lymph nodes contain many, many cells called lymphocytes, which are more commonly known as white blood cells. White blood cells are the body’s defense system against bacteria and infections.

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They release molecules into the bloodstream that make the macrophages in the vulnerable organs produce their own molecules that attract the rogue cancer cell and other macrophages, creating a very cozy environment for the future tumor to grow, served by its adoring brainwashed macrophage fans. https://jhoonline.biomedcentral.com/art ... 017-0430-2 “TAMs can promote initiation and metastasis of tumor cells... Specifically, TNF-α, VEGF, and transforming growing factor-β (TGF-β), which are derived from TAMs in cancer tissues, are believed to be transported through the bloodstream to destination organs, where they induce macrophages to produce S100A8 and serum amyloid A3. Both S100A8 and serum amyloid A3 can recruit macrophages and tumor cells to these organs and promote the formation of metastatic foci “ 4 Cancer cells convert their

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(9) stated that several tumors can express FasL, that is considered a mechanism by which tumors can escape from destruction by the immune response. The members of Bcl-2 family are as well a group of important regulatory factors in apoptosis (10) as they play an important role in mitochondria pathway-mediated apoptosis (11). BCL-2 (B-cell lymphoma 2) was firstly known as a gene whose product causes resistance to apoptosis in lymphocytes. Later studies, identified a number of both pro- as well as anti-apoptotic Bcl-2-related proteins

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If the tumor occurs in the neck, it may be visible as a lump as well as affecting breathing and

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Due this process, it allows the lymphatic system to monitor the invading microbes. The lymphatic vessels also carry a clear fluid that it bathes in the body’s tissues that is known as lymph. Another organ is lymph node that is has specialized compartments where the immune system there and can encounter antigens. It shaped is small and bean shapes that are there in neck, armpits, abdomen and groin. As mentioned above, that there is lymphatic vessels, so that the immune cells and all the foreign particles will enter then exit through outgoing lymphatic vessels.

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