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Isoxazoline Synthesis

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6.1.1:- Synthesis of Isoxazoline derivatives :- Isoxazoline are five member heterocyclic compound. isoxazole and their derivatives have received much attention because of their wide application in medicine and pesticide chemistry. Many isoxazole compound including oxacillin sulfamethoxazole have been developed as pesticides and drugs. Isoxazoline derivative synthesized by various ways [1-2]. K.S.Kumaret.al[3] reported the synthesis of isoxazolines from newly substituted chalcone by reaction with hydroxylamine hydrochloride . J.T. Desaiet al. [4] reported the ecofriendly synthesis of isoxazoline moiety containing bridge at 2 º amine and also …show more content…

[5] synthesized Mannich bases of isoxazolines derivatives by the condensation reaction of substituted acetophenone with substituted aldehydes in presence of alcoholic NaOH via chalcones intermediate. A palumbopiccionello, et. al[6] reported the synthesis of isoxazoline derivatives through Boulton –Katrizky rearrangement of 1, 2, 4, oxadiazoles. R. Bhimwal etal.[7] described the synthesis of isoxazolines via cyclisation of substituted chalcone intermediates in the presence of hydroxylamine hydrochloride and screened them for antimicrobial activity. Tejaskumar et al.[8] proposed the synthesis of isoxazolines derivatives and screened them for antimicrobial activity. Das, P. et. al [9] described the synthesis of spiro – isoxazoline and investigated the compound as anti – cancer agents. Hwang, I. T. et. al. [10] investigated the rice herbicidal activity of 5 – (2, …show more content…

For chlorination SOCl2 used. We have synthesized carboxamide derivatives using NTAA and 3-(3-benzyl-4,5-dihydroisoxazol-5-yl)pyridine and 3-benzyl-5-(3-nitrophenyl)-4,5-dihydroisoxazole by coupling reaction using dichloromethane as a solvent and the product obtained in 1.5-2 hours by stirring only. After synthesis of these carboxamide derivatives , The compounds are characterized by FTIR, 1HNMR, CMR, UV-Visible and mass spectral analysis. The analysis data is in good correlation with structure of

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Dalia El-Desoky Organic Chemistry II Lab 05 8 February 2017 Dehydration of 2-methylcyclohexanol Introduction: Dehydration is a common reaction in Organic Chemistry used to produce carbon-carbon double bonds. The dehydration mechanism involves the removal of water from an alcohol to form an alkene. In this experiment, 2-methylcyclohexanol will undergo acid catalyzed dehydration in heat to form three products: 1-methylcyclohexene, 3-methylcyclohexene, and methylenecyclohexane [1]. The reaction is carried out in a Hickman still filled with Drierite, a drying agent composed of CaSO4 which absorbs water.

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During the world war when penicillin was considered to contain the oxazole ring system at that time the chemistry of oxazole was come in concern, but the invention of oxazoles as dienes in Diels-Alder reaction and in 1, 3-dipolar cycloaddition reaction of mesoionic heterocycles give idea for progress of oxazole chemistry. Oxazole contain an oxygen atom and a pyridine type nitrogen atom at the 1 and 3 positions of the ring and like pyridine, oxazole are weekly basic substances. Oxazole be considered as derived from furan by the replacement of –CH= (methane group) from the position-3 by the azomethine nitrogen (-N=) group13. Oxazole ring is numbered as

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