Pros of gene doping in gene therapy
-Gene Doping is a form of gene modification similar to gene therapy, but rather than altering genes to treat or prevent an illness, they are changed to make normal gene perform differently (McGrath, Cowan, 2008).
-Gene doping can be utilized to restoring muscle lost to age or disease and has enter the clinical market (Gordon, Jonathan, & James, 2007)
-It can be used to denote strategies in which genes or genetic elements are introduced into cells from outside, to remedy inherited or acquired genetic disorders (Hassan, Mai, & Robert, 2005).
Cons of gene doping in gene therapy
-Molecular genetic knowledge of high-performance gene variants is so far extremely limited, fuzzy, and contradictory, so that any
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Ethical consideration regarding gene doping
-The association of therapeutic gene doping to the non-therapeutic use of genes to enhance athletic performance has affected the clinical advantage of treating disorders through gene doping
-The common sense used of animal model for experimental purposes sometimes trespasses the humane ethical values (Andy, 2004).
Balancing the ethical consideration against the needed outcomes for gene doping
-Gene doping methods and procedures are abused in healthy or highly trained humans, who thus despite their high physiological performance are also particularly susceptible to disorders, it must also be expected that the consequences are hard to predict (Andy M, 2004).
-It is imperative that experts weighs the risks, economic advantage as opposite to economic disadvantage in respect to the body’s uncertain reaction after the procedure of gene doping.
References
McGrath JC., Cowan DA., (2008).Gene doping: the hype and the reality: British Journal of Pharmacology;154, (3) PP 623–631, DOI:
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Genetically Modified athletes: Biomedical ethics, gene doping and sports. ISBN 0-415-29879-2. Retrieved Aug 3 2017, https://books.google.com/books?hl=en&lr=&id=ZerGLY9dv8IC&oi=fnd&pg=PP1&dq=Gene+doping++and+the+animal+models+ethics&ots=tp0M6ghvUs&sig=Pd5ioH3XChrPRXxX6y9xlUchtMs#v=onepage&q&f=false
Gordon S. L., Jonathan D. S., James G. (2007).Therapeutic approaches for muscle wasting disorders; Ryall Pharmacology & Therapeutics, 113 pp 461–487, Retrieved Aug 3 2017, https://www.researchgate.net/profile/James_Ryall2/publication/6544942_Therapeutic_approaches_for_muscle_wasting_disorders/links/0c96051cfd9ed7f38b000000.pdf
Hassan M.E. A., Mai M., Robert H. C.,(2005). Doping in the recombinant era: Strategies and counterstrategies;Clinical Biochemistry; 38, pp 959–965 Retrieved 03 Aug