Influenza A virus is one of the most life threatening viral infection that cause respiratory illness. This virus usually affecting the nose, throat, airways and lungs. It is so contagious that it is easily spread by having contact with the saliva through coughing and sneezing. Influenza A virus can cause mild to severe illness such as fever, headache, sore, sneezing and nausea which accompanied with loss appetite, decreased activity and food intake. Apart of that, this infection is able to cause bronchitis and pneumonia. It evolves rapidly due to high mutation rate and also may escape acquired immunity. Due to that, it can be so severe that it can result in death especially knowing that the virus itself can lead to severe pneumonia which often …show more content…
It is either by the influenza virus itself or from a bacterial infection that starts because the individual is weakened from influenza. In general, pneumonia is an inflammation of the lungs that can be quite serious or fatal. This is when the air sacs in our lungs become filled with liquid making it difficult to breathe. Poor breathing results in blockage of oxygen reaching the bloodstream which leads to the compromised ability of the cells in your body to work properly. In conclusion, without enough oxygen in our blood, the cells do not function properly and this can lead to death. The risk of death from pneumonia will be higher for people with heart disease, diabetes and weakened immune …show more content…
In this case, chronic respiratory tract infections caused by Pseudomonas aeruginosa especially when the infection occurs in both either bronchiectasis and cystic fibrosis. These are one of the most difficult infections that are very hard to control. These serious complications requires intensive care hospitalisation or sometimes it can be fatal. This is because it is well known that patients with either infections, often develop acute exacerbations with viral or bacterial superinfection. Exacerbations means worsening of COPD symptoms such as shortness of breath, quantity and colour of phlegm that usually typically lasts for several days.
Bacterial adherence to the surface of cells and respiratory tract is enhanced by influenza virus infection and is reported as a contributing factor to the increased secondary bacterial infection in influenza virus infection disease in vivo and in vitro. [1, 2] In this study, we would like to find if influenza virus infection enhanced the development of fatal pneumococcal pneumonia in chronic P. aeruginosa infection mouse